SPINK7 and EPB42

Number of citations of the paper that reports this interaction (PubMedID 12970870)
34

Data Source:
HPRD (two hybrid)

		SPINK7	EPB42
Description		serine peptidase inhibitor Kazal type 7	erythrocyte membrane protein band 4.2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Cytoskeleton Plasma Membrane Membrane Cortical Cytoskeleton Cell Periphery Ankyrin-1 Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Cell Morphogenesis Cytoskeleton Organization Regulation Of Cell Shape Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Monoatomic Ion Homeostasis Multicellular Organismal-level Iron Ion Homeostasis
Pathways
Drugs
Diseases			Hereditary spherocytosis (SPH)
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		8 interacting genes: EPB42 FTL HBA1 MRPS12 MT1G MT1H MT2A RABL6	13 interacting genes: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
Entrez ID		84651	2038
HPRD ID		16850	01517
Ensembl ID		ENSG00000145879	ENSG00000166947
Uniprot IDs		P58062	P16452
PDB IDs		2LEO	7TVZ 7TW0 7TW1 7TW3 7TW5 7TW6 7UZS 7V0K 7V0Q 8CS9 8CSL 8CSW 8CTE
Enriched GO Terms of Interacting Partners?		Detoxification Of Copper Ion Cellular Response To Cadmium Ion Cellular Response To Zinc Ion Cellular Response To Copper Ion Intracellular Zinc Ion Homeostasis Response To Copper Ion Inorganic Ion Homeostasis Response To Cadmium Ion Response To Zinc Ion Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Chemical Homeostasis Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Cellular Response To Metal Ion Intracellular Chemical Homeostasis Negative Regulation Of Growth Cellular Homeostasis Homeostatic Process Response To Metal Ion Ferritin Complex Iron Ion Binding Haptoglobin Binding Cellular Response To Erythropoietin Nitric Oxide Transport Response To Erythropoietin Regulation Of Growth Ankyrin-1 Complex Protein-glutamine Gamma-glutamyltransferase Activity Ferric Iron Binding Cellular Response To Interleukin-3 Metal Ion Binding Monocyte Activation Hemoglobin Metabolic Process Haptoglobin-hemoglobin Complex Autolysosome Hemoglobin Complex Oxygen Carrier Activity Polypeptide N-acetylgalactosaminyltransferase Activity Carbon Dioxide Transport Intracellular Copper Ion Homeostasis Oxygen Transport Erythrocyte Maturation Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Monocyte Differentiation Copper Ion Homeostasis Ferrous Iron Binding Multicellular Organismal-level Iron Ion Homeostasis One-carbon Compound Transport	Spectrin Binding Spectrin-associated Cytoskeleton Structural Constituent Of Cytoskeleton Basolateral Plasma Membrane Cortical Cytoskeleton Regulation Of Actin Filament-based Process Ankyrin-1 Complex Monoatomic Anion Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Cytoskeleton Organization A Band BLOC-1 Complex Cytoplasmic Side Of Plasma Membrane Regulation Of Actin Cytoskeleton Organization Z Disc Cytoskeletal Anchor Activity Actin Cytoskeleton Organization Organelle Organization Enzyme Binding M Band Intracellular Monoatomic Ion Homeostasis Regulation Of Biological Quality Intracellular Monoatomic Cation Homeostasis Homeostatic Process Actin Filament-based Process Bicarbonate Transport Erythrocyte Development Actin Filament Capping Protein-membrane Adaptor Activity Monoatomic Cation Homeostasis Protein Localization To Plasma Membrane Monoatomic Ion Homeostasis Negative Regulation Of Actin Filament Depolymerization Localization Within Membrane Intracellular Chemical Homeostasis Regulation Of Cytoskeleton Organization Osteoclast Differentiation Protein Localization To Cell Periphery Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Protein Localization To T-tubule PH Elevation Regulation Of Actin Filament Organization Endomembrane System Cellular Homeostasis Regulation Of Interleukin-12 Production Myeloid Cell Development Cytoskeletal Protein Binding Regulation Of Organelle Organization
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