SPINK7 and MRPS12

Number of citations of the paper that reports this interaction (PubMedID 12970870)
34

Data Source:
HPRD (two hybrid)

		SPINK7	MRPS12
Description		serine peptidase inhibitor Kazal type 7	mitochondrial ribosomal protein S12
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Small Ribosomal Subunit Ribosome Small Ribosomal Subunit Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Translation Mitochondrial Translation
Pathways			Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382)
Interacting Genes		8 interacting genes: EPB42 FTL HBA1 MRPS12 MT1G MT1H MT2A RABL6	6 interacting genes: CRMP1 ERG28 LRIF1 SPINK7 UBC UNC119
Entrez ID		84651	6183
HPRD ID		16850	04316
Ensembl ID		ENSG00000145879	ENSG00000128626
Uniprot IDs		P58062	O15235
PDB IDs		2LEO	3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2
Enriched GO Terms of Interacting Partners?		Detoxification Of Copper Ion Cellular Response To Cadmium Ion Cellular Response To Zinc Ion Cellular Response To Copper Ion Intracellular Zinc Ion Homeostasis Response To Copper Ion Inorganic Ion Homeostasis Response To Cadmium Ion Response To Zinc Ion Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Chemical Homeostasis Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Cellular Response To Metal Ion Intracellular Chemical Homeostasis Negative Regulation Of Growth Cellular Homeostasis Homeostatic Process Response To Metal Ion Ferritin Complex Iron Ion Binding Haptoglobin Binding Cellular Response To Erythropoietin Nitric Oxide Transport Response To Erythropoietin Regulation Of Growth Ankyrin-1 Complex Protein-glutamine Gamma-glutamyltransferase Activity Ferric Iron Binding Cellular Response To Interleukin-3 Metal Ion Binding Monocyte Activation Hemoglobin Metabolic Process Haptoglobin-hemoglobin Complex Autolysosome Hemoglobin Complex Oxygen Carrier Activity Polypeptide N-acetylgalactosaminyltransferase Activity Carbon Dioxide Transport Intracellular Copper Ion Homeostasis Oxygen Transport Erythrocyte Maturation Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Monocyte Differentiation Copper Ion Homeostasis Ferrous Iron Binding Multicellular Organismal-level Iron Ion Homeostasis One-carbon Compound Transport
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