CUL2 and FZD8

		CUL2	FZD8
Description		cullin 2	frizzled class receptor 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Nuclear Lumen	Golgi Apparatus Plasma Membrane Membrane Neuronal Dense Core Vesicle Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Angiogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Interacting Genes		28 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 GPS1 KAT2A KHNYN MKNK2 NEDD8 RNF7 SAP130 SENP8 TRIP12 UBC UBE2D1 UBE2D3 UBE2M VHL ZER1 ZYG11B	5 interacting genes: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		8453	8325
HPRD ID		06786	05852
Ensembl ID		ENSG00000108094	ENSG00000177283
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 A0A8I5KVR3 B7Z1Y1 Q13617	Q9H461
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 7PLO 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8PQL 8Q7R 8QU8 8R5H 8RWZ 8RX0 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH	5UN5 5UN6 6NDZ 8X0T
Enriched GO Terms of Interacting Partners?		Protein Neddylation Post-translational Protein Modification Protein Modification By Small Protein Conjugation Regulation Of Protein Neddylation Protein Modification Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Protein Metabolic Process Cullin Family Protein Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Proteolysis Cul2-RING Ubiquitin Ligase Complex Regulation Of Primary Metabolic Process Ubiquitin Ligase Complex Nucleus Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Protein Ubiquitination Ubiquitin Conjugating Enzyme Binding Regulation Of Macromolecule Metabolic Process Protein Deneddylation Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Protein Modification Process Nucleoplasm Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process NEDD8 Transferase Activity Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process Positive Regulation Of Metabolic Process DeNEDDylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Catabolic Process Protein Polyubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity	Midbrain Dopaminergic Neuron Differentiation Wnt Receptor Activity Canonical Wnt Signaling Pathway Wnt-protein Binding Frizzled Binding Dopaminergic Neuron Differentiation Wnt-Frizzled-LRP5/6 Complex Coreceptor Activity Wnt Signaling Pathway Toxin Transmembrane Transporter Activity Wnt Signalosome Central Nervous System Neuron Differentiation Midbrain Development Response To Peptide Hormone Neuron Differentiation Bone Development Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Anion Channel Activity Cell-cell Signaling Involved In Mammary Gland Development Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of Cell Proliferation In Midbrain Central Nervous System Morphogenesis Diencephalon Development Neurogenesis Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Regulation Of Fat Cell Differentiation Cell-cell Signaling Signaling Response To Hormone Morphogenesis Of A Branching Epithelium Norrin Signaling Pathway Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Communication Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Mesodermal Cell Migration Apoptotic Process Involved In Blood Vessel Morphogenesis Negative Regulation Of Cell Differentiation Extracellular Matrix-cell Signaling Cell Proliferation In Midbrain Retinal Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier Chemorepulsion Of Axon
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