CDC25B and BRSK2

Number of citations of the paper that reports this interaction (PubMedID 15150265)
0

Data Source:
HPRD (in vitro)

		CDC25B	BRSK2
Description		cell division cycle 25B	BR serine/threonine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton	Cytoplasm Endoplasmic Reticulum Centrosome Cytoskeleton Perinuclear Region Of Cytoplasm Distal Axon
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity ATPase Binding ATPase Regulator Activity Protein Serine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Female Meiosis I Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cytokinesis Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Apoptotic Process Nervous System Development Axonogenesis Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Establishment Of Cell Polarity Actin Cytoskeleton Organization Neuron Differentiation ERAD Pathway Neuron Projection Morphogenesis Regulation Of Axonogenesis Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Synaptic Vesicle Clustering
Pathways		Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs		L-cysteic acid
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Cognitive decline rate in late mild cognitive impairment ( 26252872) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) SAPHO syndrome ( 33816493)	Brain morphology (MOSTest) ( 32665545) Gout ( 32238385) Heroin dependence ( 27936112) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		28 interacting genes: AATK AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CDK5 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR PSME3 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ	12 interacting genes: CDC25B CDC25C COPS5 MAGI3 MAPT NHERF1 NHERF2 SCRIB SNX27 TRAF6 VCP WEE1
Entrez ID		994	9024
HPRD ID		00307	11611
Ensembl ID		ENSG00000101224	ENSG00000174672
Uniprot IDs		B3KS38 B4DIG0 B4DQZ3 B4DRC3 E1YMX4 G8JLH2 P30305	A0A140VJF6 B4DLY3 Q8IWQ3
PDB IDs		1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Kinase Activity Protein Phosphorylation Phosphoserine Residue Binding Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Protein Domain Specific Binding Regulation Of Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition Rhythmic Process Cell Cycle Phase Transition Regulation Of Cell Cycle Process Transferase Activity DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Signal Transduction Cytosol Intracellular Signaling Cassette Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle MAPK Cascade ATP Binding Signal Transduction In Response To DNA Damage Nucleus Regulation Of Intracellular Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Protein Modification Process Nucleoplasm Centrosome Estrogen Response Element Binding Protein Sequestering Activity Negative Regulation Of RNA Metabolic Process Apoptotic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process	Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Establishment Of Cell Polarity Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Protein Modification Process Establishment Or Maintenance Of Cell Polarity G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Inclusion Body Assembly Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Establishment Of Apical/basal Cell Polarity Positive Regulation Of Meiotic Cell Cycle Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Mitotic Cell Cycle Phase Transition Regulation Of Protein Localization To Synapse Cell Cycle Phase Transition Protein Kinase Binding Protein-membrane Adaptor Activity Inner Ear Receptor Cell Stereocilium Organization Cellular Localization Protein Localization To Plasma Membrane Establishment Of Localization In Cell Localization Within Membrane Negative Regulation Of Mitotic Cell Cycle Cytoplasm Regulation Of Catalytic Activity Glutamatergic Synapse Protein Localization To Cell Periphery Immunological Synapse Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Cycle Process Regulation Of Kinase Activity Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding
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