CDC25B

Description		cell division cycle 25B
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Female Meiosis I Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cytokinesis Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs		L-cysteic acid
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Cognitive decline rate in late mild cognitive impairment ( 26252872) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) SAPHO syndrome ( 33816493)
Interacting Genes		28 interacting genes: AATK AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CDK5 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR PSME3 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		994
HPRD ID		00307
Ensembl ID		ENSG00000101224
Uniprot IDs		B3KS38 B4DIG0 B4DQZ3 B4DRC3 E1YMX4 G8JLH2 P30305
PDB IDs		1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Kinase Activity Protein Phosphorylation Phosphoserine Residue Binding Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Protein Domain Specific Binding Regulation Of Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition Rhythmic Process Cell Cycle Phase Transition Regulation Of Cell Cycle Process Transferase Activity DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Signal Transduction Cytosol Intracellular Signaling Cassette Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle MAPK Cascade ATP Binding Signal Transduction In Response To DNA Damage Nucleus Regulation Of Intracellular Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Protein Modification Process Nucleoplasm Centrosome Estrogen Response Element Binding Protein Sequestering Activity Negative Regulation Of RNA Metabolic Process Apoptotic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process
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