DOT1L and MLLT6

Number of citations of the paper that reports this interaction (PMID 19864429)
17

Data Source:
BioGRID (two hybrid, two hybrid, pull down, affinity chromatography technology)

		DOT1L	MLLT6
Gene Name		DOT1-like histone H3K79 methyltransferase	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	DNA Binding Protein Binding Transcription Factor Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K79 Specific)	Protein Binding Zinc Ion Binding
	Biological Process	Chromatin Silencing Histone H3-K79 Methylation Regulation Of JAK-STAT Cascade Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding	Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391950) Osteoarthritis ( 22566624)
Protein-Protein Interactions		4 interactors: HIST3H3 MLLT10 MLLT6 STAT1	20 interactors: APP CASK CEBPE CEBPG CEP44 CRX DOT1L ENOX2 IKBKG KRTAP10-8 MED15 MEOX2 SPRY2 TCF12 TCF4 UBE2G2 UBQLN1 UBQLN4 WHSC1L1 ZBTB22
Entrez ID		84444	4302
HPRD ID		10455	08978
Ensembl ID		ENSG00000104885	ENSG00000108292
Uniprot IDs		Q8TEK3	P55198
PDB IDs		1NW3 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macrophage Fusion Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesenchymal Cell Differentiation Involved In Kidney Development Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Differentiation Involved In Metanephros Development Cellular Response To Interferon-beta Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Metanephric Mesenchyme Development Response To Interferon-beta Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Growth Hormone Cell Differentiation Involved In Kidney Development Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mesenchymal Cell Proliferation Response To Exogenous DsRNA Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling JAK-STAT Cascade Positive Regulation Of Smooth Muscle Cell Proliferation	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Binding Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Nitrogen Compound Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Organ Development Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Growth Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Neuron Differentiation Regulation Of Cellular Process Regulation Of Protein Metabolic Process Ultradian Rhythm Histone H3-K79 Methylation Positive Regulation Of Photoreceptor Cell Differentiation Anatomical Structure Development Neuron Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway System Development Regulation Of Neurogenesis Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Tagcloud ?		aberrant balanced blasts catalyze considerable depending deregulated disturbed drivers histones indirectly leukemia leukemic lysine marks methylated methyltransferases mll1 oncogenic originating progenitor recurrently repressing residue setd2 tightly transformed translocations writers	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt4 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Difference) ?		aberrant balanced blasts catalyze considerable depending deregulated disturbed drivers histones indirectly leukemia leukemic lysine marks methylated methyltransferases mll1 oncogenic originating progenitor recurrently repressing residue setd2 tightly transformed writers	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt4 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 zbtb16
Tagcloud (Intersection) ?		translocations