C15orf48 and ABL2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		C15orf48	ABL2
Gene Name		chromosome 15 open reading frame 48	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion	Phagocytic Cup Cytosol Actin Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine
	Molecular Function		Magnesium Ion Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process		Cellular Protein Modification Process Phagocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Neuron Remodeling Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Regulation Of Endocytosis Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Cellular Protein Localization Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Neuromuscular Process Controlling Balance Actin Filament Bundle Assembly Positive Regulation Of Oxidoreductase Activity Bergmann Glial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Dendritic Spine Maintenance Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Role of Abl in Robo-Slit signaling Axon guidance Signaling by Robo receptor
Drugs			Adenosine triphosphate Dasatinib 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS			IgE grass sensitization ( 22036096)
Protein-Protein Interactions		2 interactors: ABL2 TSSK3	25 interactors: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 NEDD4 NEDD4L OIP5 PSMA7 RIN1 SIVA1 SORBS2 TPD52L1 TRIP10
Entrez ID		84419	27
HPRD ID		16332	01259
Ensembl ID		ENSG00000166920	ENSG00000143322
Uniprot IDs		Q9C002	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Secretion Bergmann Glial Cell Differentiation Neuron Remodeling Dendritic Spine Maintenance Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Dendritic Spine Organization Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Endothelial Cell Apoptotic Process Cellular Component Maintenance Exploration Behavior Neuron Maturation Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Substrate-dependent Cell Migration Protein Phosphorylation Peptidyl-tyrosine Autophosphorylation Regulation Of Extracellular Matrix Organization Positive Regulation Of Oxidoreductase Activity Regulation Of Actin Cytoskeleton Reorganization Astrocyte Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Cerebellum Morphogenesis Positive Regulation Of Interferon-gamma Production Hindbrain Morphogenesis Positive Regulation Of Phospholipase C Activity Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Alpha-beta T Cell Differentiation Visual Learning Visual Behavior Positive Regulation Of Protein Binding Alpha-beta T Cell Activation Actin Filament Bundle Assembly Cellular Response To Retinoic Acid Phosphorylation Positive Regulation Of Phospholipase Activity Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Balance Dendrite Morphogenesis Associative Learning Regulation Of Phospholipase Activity Regulation Of Interferon-gamma Production Positive Regulation Of Lipase Activity Positive Regulation Of Cytokine Secretion Regulation Of Autophagy Cerebellum Development	Regulation Of Signaling Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Communication Protein Autophosphorylation Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Signaling Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Locomotion Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Growth Factor Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Immune System Process Positive Regulation Of MAPK Cascade Cellular Protein Modification Process Regulation Of Protein Metabolic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Response To Stimulus Positive Regulation Of Metabolic Process Response To Stress Regulation Of Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?			abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Difference) ?			abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Intersection) ?