COXFA4L3 and ABL2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		COXFA4L3	ABL2
Description		cytochrome c oxidase associated subunit FA4L3	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Respiratory Chain Complex IV	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity Enzyme Binding Manganese Ion Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Response To Bacterium	Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Protein Modification Process Cellular Response To Retinoic Acid Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Cell Motility Positive Regulation Of T Cell Migration
Pathways			Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling RAC1 GTPase cycle RAC3 GTPase cycle Negative regulation of FLT3
Drugs			ATP Dasatinib XL228 K-00546 Fostamatinib
Diseases
GWAS			IgE grass sensitization ( 22036096)
Interacting Genes		3 interacting genes: ABL2 FBXO7 TSSK3	34 interacting genes: ABL1 AR BCR CAT COXFA4L3 CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PRRG4 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1
Entrez ID		84419	27
HPRD ID		16332	01259
Ensembl ID		ENSG00000166920	ENSG00000143322
Uniprot IDs		Q9C002	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?		Regulation Of Neuron Projection Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Actin Monomer Binding Manganese Ion Binding Cellular Response To Retinoic Acid Regulation Of Axon Extension Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Response To Retinoic Acid Regulation Of Axonogenesis Positive Regulation Of Neuron Projection Development Lewy Body Core Regulation Of Cell Development Positive Regulation Of Establishment Of T Cell Polarity Actin Filament Binding Magnesium Ion Binding Regulation Of Microvillus Length Anion Binding Regulation Of Establishment Of T Cell Polarity Regulation Of Cellular Component Organization Regulation Of Locomotion Negative Regulation Of Cell Development T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell ATP Binding Phosphorylation Regulation Of Multicellular Organismal Process Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Protein Phosphorylation Regulation Of Autophagy Positive Regulation Of Cell Projection Organization Actin Filament Depolymerization Regulation Of Developmental Growth Regulation Of Cell Projection Size Regulation Of Neurogenesis Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Smooth Muscle Cell Migration Regulation Of Multicellular Organismal Development Regulation Of Cell Growth Barbed-end Actin Filament Capping	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Phosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Population Proliferation Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Migration Basal Plasma Membrane Transferase Activity Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Biological Quality Regulation Of Cell Motility Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion
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