BRMS1L and RBBP4

Number of citations of the paper that reports this interaction (PMID 15451426)
21

Data Source:
HPRD (in vivo)

		BRMS1L	RBBP4
Gene Name		breast cancer metastasis-suppressor 1-like	retinoblastoma binding protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Sin3-type Complex	Nuclear Chromatin Nucleus Nucleoplasm Sin3 Complex NuRD Complex NURF Complex CAF-1 Complex ESC/E(Z) Complex Protein Complex
	Molecular Function	Histone Deacetylase Activity Histone Deacetylase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Histone Deacetylation Regulation Of Growth	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Gene Expression Chromatin Assembly CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle
Pathways			Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ACTN2 AMOTL2 BRMS1 CCDC67 EXOC5 HDAC1 HDAC2 ING1 LINC00152 MID2 RBBP4 RBBP7 RBP1 SAP30 SIN3A	50 interactors: AEBP2 ANXA7 BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP DHX30 EED ESR1 EZH2 GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HIST1H1A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMOX2 ING1 LINC00152 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 NR2E3 RB1 RBBP7 RBP1 RPN1 RPN2 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUV39H1 TK1 TSSK3 XRCC6
Entrez ID		84312	5928
HPRD ID		16564	04232
Ensembl ID		ENSG00000100916	ENSG00000162521
Uniprot IDs		B2RD65 Q5PSV4	Q09028
PDB IDs			2XU7 3GFC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression Histone Deacetylation Protein Deacetylation Organelle Organization Negative Regulation Of RNA Biosynthetic Process ATP-dependent Chromatin Remodeling Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone Modification Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Fungiform Papilla Formation Fungiform Papilla Morphogenesis Transcription, DNA-templated Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Regulation Of Transcription From RNA Polymerase II Promoter Tongue Morphogenesis Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of Gene Expression Negative Regulation Of Viral Transcription Blood Coagulation Hemostasis CENP-A Containing Nucleosome Assembly Histone H3 Deacetylation Regulation Of Cell Death RNA Metabolic Process Tongue Development Histone Exchange DNA Replication-independent Nucleosome Assembly Epithelial Cell Differentiation Gene Expression Regulation Of Body Fluid Levels	Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Organelle Organization Histone Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Metabolic Process Chromatin Remodeling Histone Deacetylation Positive Regulation Of Transcription, DNA-templated Protein Deacetylation Biosynthetic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Chromatin Silencing Histone H3-K9 Modification Positive Regulation Of Metabolic Process Metabolic Process
Tagcloud ?			bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top
Tagcloud (Difference) ?			bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top
Tagcloud (Intersection) ?