CHCHD6 and SAMM50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		CHCHD6	SAMM50
Description		coiled-coil-helix-coiled-coil-helix domain containing 6	SAMM50 sorting and assembly machinery component
Image		No pdb structure
GO Annotations	Cellular Component	SAM Complex Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex	SAM Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Membrane Extracellular Exosome MIB Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	DNA Damage Response Inner Mitochondrial Membrane Organization Cristae Formation	Inner Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Cristae formation	Mitochondrial protein import Cristae formation RAC2 GTPase cycle
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Diabetic maculopathy with decreased visual acuity in type 2 diabetes ( 31264924) Youthful appearance (self-reported) ( 32339537)	Alanine aminotransferase levels ( 30718733) Cholesterol, total ( 26780889) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 23823483) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134 34841290) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Total cholesterol levels ( 28334899) Type 2 diabetes ( 30054458)
Interacting Genes		3 interacting genes: APP FBXO7 SAMM50	10 interacting genes: A1BG CHCHD3 CHCHD6 GABARAP HMGB2 MAP1LC3B MAP1LC3C MEOX2 UBC VDAC1
Entrez ID		84303	25813
HPRD ID		13047	10826
Ensembl ID		ENSG00000159685	ENSG00000100347
Uniprot IDs		Q9BRQ6	Q9Y512
PDB IDs			6YOO 6YOP
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Establishment Of Protein Localization To Mitochondrion Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Outer Membrane Regulation Of Neuron Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Mitochondrion Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Establishment Of Protein Localization To Organelle Protein Heterodimerization Activity Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Apoptotic Signaling Pathway SAM Complex	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Membrane Autophagosome Maturation Mitochondrial Crista Junction MICOS Complex Autophagy Of Mitochondrion Ceramide Binding Autophagosome SAM Complex MIB Complex Ubiquitin Protein Ligase Binding Autophagosome Assembly Cristae Formation Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Inner Mitochondrial Membrane Organization Response To Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cellular Response To Nutrient Levels Endomembrane System Autophagy Microtubule Cellular Response To Stress Non-sequence-specific DNA Binding, Bending Mitochondrion Organelle Organization Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Protein K48-linked Ubiquitination Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Axoneme Response To Nutrient Levels Somite Specification Voltage-gated Monoatomic Anion Channel Activity Supercoiled DNA Binding Porin Activity Regulation Of Calcium Import Into The Mitochondrion Regulation Of Protein K48-linked Ubiquitination Response To Stress Mitochondrial Permeability Transition Pore Complex DNA Geometric Change Mitochondrial Membrane Neuron-neuron Synaptic Transmission
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