DRC8 and TNNI2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DRC8	TNNI2
Name		dynein regulatory complex subunit 8	troponin I2, fast skeletal type
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Motile Cilium Cell Projection Organelle Sperm Principal Piece	Nucleus Cytosol Troponin Complex
	Molecular Function	Calcium Ion Binding Protein Binding	Actin Binding Protein Binding Troponin T Binding
	Biological Process	None	Skeletal Muscle Contraction Positive Regulation Of DNA-templated Transcription Cardiac Muscle Contraction
Pathways		None	Striated Muscle Contraction
Diseases		None	Distal arthrogryposis (DA)
GWAS		No GWAS studies recorded	Celiac disease ( 23936387 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Inflammatory bowel disease ( 23128233 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
Novel Interactors		None recorded	1 novel interactors: TH
Interacting Genes		5 interacting genes: ANTKMT MRPL12 TCL1B TNNI1 TNNI2	21 interacting genes: ACTB AIRIM CALM1 CTNNA3 DCAF11 DRC8 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2
Entrez ID		84288	7136
HPRD ID		14423	01843
Ensembl ID		ENSG00000203666	ENSG00000130598
Uniprot IDs		Q5VUJ9	P48788
PDB IDs		8J07	2MKP 7KAA
GO Terms Enriched among Interactors		Troponin Complex Skeletal Muscle Contraction Cardiac Muscle Contraction Striated Muscle Contraction Troponin T Binding Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Muscle Contraction Mitochondrial Transcription Transition Between Fast And Slow Fiber Muscle System Process Peptidyl-lysine Trimethylation Regulation Of Skeletal Muscle Adaptation Actin Binding Peptidyl-lysine Methylation Regulation Of ATP Biosynthetic Process Protein-lysine N-methyltransferase Activity	Troponin Complex Regulation Of Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Regulation Of System Process Nuclear Receptor Activity Striated Muscle Contraction Muscle Contraction Troponin I Binding Troponin T Binding Muscle System Process Transition Between Fast And Slow Fiber System Process Estrogen Response Element Binding Regulation Of Skeletal Muscle Adaptation Titin Binding Contractile Muscle Fiber Tropomyosin Binding Calcium-dependent Protein Binding Motile Cilium Intracellular Receptor Signaling Pathway Calyx Of Held Regulation Of Striated Muscle Contraction Nuclear Steroid Receptor Activity Axonemal A Tubule Inner Sheath Calcium Channel Complex Regulation Of Cardiac Muscle Cell Action Potential Steroid Binding Respiratory System Process Cilium Axonemal Microtubule Calcium Ion Binding Eye Photoreceptor Cell Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Photoreceptor Cell Development Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Regulation Of Muscle Filament Sliding Speed Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Positive Regulation Of Calcium-dependent ATPase Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Substantia Nigra Development Actin Filament-based Process Cytosol Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Heart Contraction