COQ5 and SLC13A1

Number of citations of the paper that reports this interaction (PubMedID 18407958)
55

Data Source:
BioGRID (protein complementation assay)

		COQ5	SLC13A1
Description		coenzyme Q5, methyltransferase	solute carrier family 13 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Extrinsic Component Of Mitochondrial Inner Membrane Protein-containing Complex Ubiquinone Biosynthesis Complex	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Methyltransferase Activity 2-methoxy-6-polyprenyl-1,4-benzoquinol Methyltransferase Activity Transferase Activity	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity
	Biological Process	Ubiquinone Biosynthetic Process Methylation	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport
Pathways		Ubiquinol biosynthesis	Sodium-coupled sulphate, di- and tri-carboxylate transporters
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Refractive error ( 32231278) Type 1 diabetes nephropathy ( 23028342)	Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) High density lipoprotein cholesterol levels ( 30498476) Systolic blood pressure ( 30578418)
Interacting Genes		2 interacting genes: SHANK3 SLC13A1	31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3
Entrez ID		84274	6561
HPRD ID		17560	08394
Ensembl ID		ENSG00000110871	ENSG00000081800
Uniprot IDs		Q5HYK3	A4D0X1 Q2NKK0 Q9BZW2
PDB IDs			8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z
Enriched GO Terms of Interacting Partners?		Ciliary Membrane Sulfate Transmembrane Transport Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Secondary Active Sulfate Transmembrane Transporter Activity MKS Complex Protein Localization To Ciliary Transition Zone Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Striatal Medium Spiny Neuron Differentiation Postsynaptic Specialization Assembly Neurotransmitter-gated Ion Channel Clustering Solute:sodium Symporter Activity Auditory Behavior Regulation Of Long-term Synaptic Depression Mechanosensory Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Brain Morphogenesis Vocalization Behavior Positive Regulation Of Long-term Synaptic Potentiation Postsynaptic Specialization Organization Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Binding Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Organization Ciliary Transition Zone Cell Volume Homeostasis Negative Regulation Of Actin Filament Bundle Assembly Forebrain Neuron Differentiation Positive Regulation Of Dendritic Spine Development Plasma Membrane Bounded Cell Projection Organization Regulation Of Long-term Synaptic Potentiation Neuron Projection Organization Regulation Of Dendritic Spine Morphogenesis	Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding
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