ALKBH7 and KIAA1217

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALKBH7	KIAA1217
Description		alkB homolog 7	KIAA1217
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Centrosome Cytoskeleton
	Molecular Function	Protein Binding Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity	Protein Binding
	Biological Process	Fatty Acid Metabolic Process DNA Damage Response Regulation Of Lipid Storage Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death	Embryonic Skeletal System Development
Pathways
Drugs
Diseases
GWAS			Breast cancer and/or colorectal cancer ( 29698419) Cognitive function in longevity ( 33607172) Cognitive performance ( 20125193) Coronary artery disease ( 29212778) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Homeostasis model assessment of insulin resistance ( 33381925) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Moderate-to-late spontaneous preterm birth ( 31194736) Obesity (early onset extreme) ( 23563609) Schizophrenia ( 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		6 interacting genes: APP B9D2 CENPN CFTR CIMIP1 KIAA1217	23 interacting genes: ABI1 ABI2 ALKBH7 EXOC8 EXOSC5 FHL2 FXR2 GCC1 GOLGA2 HSBP1 INCA1 KRT15 KRT27 KRT31 NCK2 PTK6 RINT1 SIAH1 SORBS3 TEX11 TRAF1 TRAF2 VPS52
Entrez ID		84266	56243
HPRD ID		15425	11132
Ensembl ID		ENSG00000125652	ENSG00000120549
Uniprot IDs		Q9BT30	B7ZM29 Q5T5P2
PDB IDs		4QKB 4QKD 4QKF
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Response To Purine-containing Compound Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Recycling Endosome Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cell Maturation Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Enamel Mineralization Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Transepithelial Water Transport Regulation Of Spontaneous Synaptic Transmission Early Endosome Membrane NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Tooth Mineralization Developmental Maturation Axon Choice Point Recognition Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity	Signaling Adaptor Activity Supramolecular Fiber Organization Cytosol Identical Protein Binding Positive Regulation Of Apoptotic Signaling Pathway Actin-based Cell Projection Structural Constituent Of Skin Epidermis Thioesterase Binding SCAR Complex Intermediate Filament Organization Regulation Of Apoptotic Signaling Pathway Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Protein Kinase Activity Filopodium Tip Structural Constituent Of Cytoskeleton Regulation Of Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Cytoskeletal Anchor Activity Golgi Vesicle Transport Tumor Necrosis Factor Receptor Binding Cytoplasm Regulation Of Protein Modification Process Intermediate Filament Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly Vesicle Membrane Meiotic Gene Conversion Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Protein Phosphorylation Lamellipodium Organization Structural Molecule Activity Negative Regulation Of Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Cytoskeleton Organization Regulation Of Apoptotic Process Syntaxin Binding Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Atrial Cardiac Muscle Cell Development Cellular Developmental Process Cytoskeleton Regulation Of Phosphorylation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Actin Polymerization Or Depolymerization Zonula Adherens Assembly
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