ALKBH7 and CENPN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALKBH7	CENPN
Description		alkB homolog 7	centromere protein N
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Protein Binding Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity	Protein Binding
	Biological Process	Fatty Acid Metabolic Process DNA Damage Response Regulation Of Lipid Storage Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death	Chromosome Segregation CENP-A Containing Chromatin Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: APP B9D2 CENPN CFTR CIMIP1 KIAA1217	4 interacting genes: ALKBH7 DNAAF19 OSGIN1 TSSK3
Entrez ID		84266	55839
HPRD ID		15425	12528
Ensembl ID		ENSG00000125652	ENSG00000166451
Uniprot IDs		Q9BT30	Q96H22
PDB IDs		4QKB 4QKD 4QKF	6BUZ 6C0W 6EQT 6MUO 6MUP 7PKN 7QOO 7R5S 7R5V 7U46 7U47 7U4D 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Response To Purine-containing Compound Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Recycling Endosome Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cell Maturation Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Enamel Mineralization Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Transepithelial Water Transport Regulation Of Spontaneous Synaptic Transmission Early Endosome Membrane NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Tooth Mineralization Developmental Maturation Axon Choice Point Recognition Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity
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