BBOX1 and SHTN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		BBOX1	SHTN1
Description		gamma-butyrobetaine hydroxylase 1	shootin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Lamellipodium Filopodium Axon Growth Cone Cell Leading Edge Cell Projection Perikaryon Axonal Growth Cone Perinuclear Region Of Cytoplasm
	Molecular Function	Iron Ion Binding Protein Binding Zinc Ion Binding Gamma-butyrobetaine Dioxygenase Activity Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Dioxygenase Activity	Protein Binding Kinesin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Carnitine Biosynthetic Process	Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Axonogenesis Cdc42 Protein Signal Transduction Netrin-activated Signaling Pathway Positive Regulation Of Axon Extension Neuron Projection Morphogenesis Cytoplasmic Actin-based Contraction Involved In Cell Motility Endoplasmic Reticulum Polarization Actin Filament Bundle Retrograde Transport Regulation Of Establishment Of Cell Polarity Regulation Of Neuron Migration Positive Regulation Of Neuron Migration
Pathways		Carnitine synthesis	Recycling pathway of L1
Drugs		Ascorbic acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Serum metabolite levels ( 33031748)	Age at first sexual intercourse ( 34211149) Cortical surface area ( 32963231) Cortical volume ( 32963231) Lysophosphatidylethanolamine levels ( 31551469)
Interacting Genes		3 interacting genes: HSPB3 SHTN1 STUB1	20 interacting genes: BBOX1 DSCAM ESRRG EXOC6B FABP3 IGL IKBKG LNX1 LNX2 MEGF10 NEDD4 NME7 NRIP1 PCNT PRMT2 TFCP2 TNIP1 TP53BP2 WEE2-AS1 ZCCHC17
Entrez ID		8424	57698
HPRD ID		04498	11155
Ensembl ID		ENSG00000129151	ENSG00000187164
Uniprot IDs		O75936	A0MZ66
PDB IDs		3MS5 3N6W 3O2G 4BG1 4BGK 4BGM 4BHF 4BHG 4BHI 4C5W 4C8R 4CWD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Chaperone-mediated Protein Complex Assembly Endoplasmic Reticulum Polarization Actin Filament Bundle Retrograde Transport Response To Temperature Stimulus Calcium Activated Galactosylceramide Scrambling Negative Regulation Of Vascular Associated Smooth Muscle Contraction Cdc42 Protein Signal Transduction Ubiquitin Conjugating Enzyme Complex Calcium Activated Phospholipid Scrambling Calcium Activated Phosphatidylcholine Scrambling Cytoplasmic Actin-based Contraction Involved In Cell Motility Chaperone-mediated Autophagy Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway TPR Domain Binding Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Vasoconstriction Regulation Of Vascular Associated Smooth Muscle Contraction Response To Misfolded Protein Cellular Response To Misfolded Protein Negative Regulation Of Smooth Muscle Contraction Netrin-activated Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of ERAD Pathway Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Smooth Muscle Cell Apoptotic Process Misfolded Protein Binding Positive Regulation Of Neuron Migration Intracellularly Calcium-gated Chloride Channel Activity Phospholipid Scramblase Activity Negative Regulation Of Muscle Contraction Plasma Membrane Phospholipid Scrambling ERBB2 Signaling Pathway Regulation Of Establishment Of Cell Polarity Detection Of Temperature Stimulus Positive Regulation Of Mitophagy Regulation Of ERAD Pathway Axonal Growth Cone Positive Regulation Of Autophagy Of Mitochondrion R-SMAD Binding Regulation Of Establishment Or Maintenance Of Cell Polarity Cellular Response To Topologically Incorrect Protein
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