ZNRF3 and RSPO1

Number of citations of the paper that reports this interaction (PMID 24165923)
3

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ZNRF3	RSPO1
Gene Name		zinc and ring finger 3	R-spondin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Ligase Activity	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Heparin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Wnt Receptor Catabolic Process Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Male Meiosis Regulation Of Gene Expression Positive Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Male Germ Cell Proliferation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Waist-hip ratio ( 20935629)
Protein-Protein Interactions		3 interactors: GFI1B RSPO1 UBE2N	2 interactors: RNF43 ZNRF3
Entrez ID		84133	284654
HPRD ID		11737	08288
Ensembl ID		ENSG00000183579	ENSG00000169218
Uniprot IDs		Q9ULT6	Q2MKA7
PDB IDs			4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4KNG 4KT1 4LI2
Enriched GO Terms of Interacting Partners?		Regulation Of Histone Modification Regulation Of Chromosome Organization Regulation Of Male Germ Cell Proliferation Regulation Of Histone Ubiquitination Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Double-strand Break Processing Positive Regulation Of Non-canonical Wnt Signaling Pathway Chromatin Modification Organelle Organization Postreplication Repair Chromatin Organization Regulation Of Histone H3-K4 Methylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Receptor Internalization Protein K63-linked Ubiquitination Positive Regulation Of Protein Modification Process DNA Catabolic Process, Exonucleolytic Regulation Of Organelle Organization Histone Ubiquitination Positive Regulation Of DNA Repair Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Chromosome Organization Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Histone Methylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Male Meiosis Positive Regulation Of Protein Metabolic Process Regulation Of DNA Repair Positive Regulation Of Signal Transduction Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Ubiquitin-protein Transferase Activity Canonical Wnt Signaling Pathway	Wnt Receptor Catabolic Process Receptor Catabolic Process Receptor Metabolic Process Stem Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cell Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Non-canonical Wnt Signaling Pathway Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Catabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Organ Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process
Tagcloud ?		22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely kremen1 mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize
Tagcloud (Difference) ?		22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely kremen1 mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize
Tagcloud (Intersection) ?