ZNRF3 and RSPO1

Number of citations of the paper that reports this interaction (PubMedID 25504990)
44

Data Source:
BioGRID (fluorescent resonance energy transfer, pull down, pull down)

		ZNRF3	RSPO1
Description		zinc and ring finger 3	R-spondin 1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Heparin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Limb Development Regulation Of Canonical Wnt Signaling Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination
Drugs
Diseases			46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		A body shape index ( 34021172) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 30487518 27618448) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448 30487518 29403010) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 25086665 29422604) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418 27618448) Type 2 diabetes ( 32499647) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494)	Axial length ( 24144296) Epithelial ovarian cancer ( 25581431) Eyebrow thickness ( 26926045) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 30054594 31959993)
Interacting Genes		9 interacting genes: C3orf52 EPOR GFI1B HOXA1 HSPB1 RNF43 RSPO1 RSPO3 UBE2N	2 interacting genes: LGR4 ZNRF3
Entrez ID		84133	284654
HPRD ID		11737	08288
Ensembl ID		ENSG00000183579	ENSG00000169218
Uniprot IDs		Q9ULT6	Q2MKA7
PDB IDs		8G4Y 8XFP 8XFS 8XFT 8Y69	4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4CDK 4KNG 4KT1 4LI2 4QXF 8WVU
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Erythropoietin Receptor Activity Semicircular Canal Formation Negative Regulation Of Protein Kinase C Signaling Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Frizzled Binding Abducens Nerve Formation Optokinetic Behavior Wnt Receptor Catabolic Process Ubiquitin Binding Positive Regulation Of Canonical Wnt Signaling Pathway Protein Kinase C Inhibitor Activity UBC13-MMS2 Complex	Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Metanephric Glomerulus Development Wnt Receptor Catabolic Process Regulation Of Wnt Signaling Pathway Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Metanephric Nephron Tubule Morphogenesis Negative Regulation Of Non-canonical Wnt Signaling Pathway Intestinal Stem Cell Homeostasis Nephron Tubule Morphogenesis Male Genitalia Development Glomerulus Development Renal Tubule Morphogenesis Bone Remodeling Cell Population Proliferation Protein-hormone Receptor Activity Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Receptor Catabolic Process Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Toll-like Receptor Signaling Pathway Reproductive System Development Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Morphogenesis Of An Epithelium Genitalia Development Regulation Of Kidney Development Regulation Of Toll-like Receptor Signaling Pathway Frizzled Binding Hair Follicle Development Negative Regulation Of Cold-induced Thermogenesis Receptor Metabolic Process Digestive Tract Development Regulation Of Morphogenesis Of A Branching Structure Limb Development Negative Regulation Of Signal Transduction Bone Mineralization Circadian Regulation Of Gene Expression Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of Cell Communication Negative Regulation Of Signaling Hair Cycle Process Stem Cell Proliferation Regulation Of Animal Organ Morphogenesis Tissue Remodeling Biomineral Tissue Development Positive Regulation Of Canonical Wnt Signaling Pathway Epithelial Tube Morphogenesis Cell Surface Receptor Signaling Pathway Osteoblast Differentiation Circadian Rhythm
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