RSPO1

Gene Name		R-spondin 1
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Heparin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Male Meiosis Regulation Of Gene Expression Positive Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Male Germ Cell Proliferation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: RNF43 ZNRF3
Entrez ID		284654
HPRD ID		08288
Ensembl ID		ENSG00000169218
Uniprot IDs		Q2MKA7
PDB IDs		4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4KNG 4KT1 4LI2
Enriched GO Terms of Interacting Partners?		Wnt Receptor Catabolic Process Receptor Catabolic Process Receptor Metabolic Process Stem Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cell Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Non-canonical Wnt Signaling Pathway Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Catabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Organ Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process
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