ZNRF3 and GFI1B

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNRF3	GFI1B
Description		zinc and ring finger 3	growth factor independent 1B transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nucleoplasm Transcription Regulator Complex Plasma Membrane Nuclear Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Limb Development Regulation Of Canonical Wnt Signaling Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hemopoiesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of FZD by ubiquitination
Drugs
Diseases
GWAS		A body shape index ( 34021172) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 30487518 27618448) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448 30487518 29403010) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 25086665 29422604) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418 27618448) Type 2 diabetes ( 32499647) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494)	Basophil percentage of white cells ( 27863252) Cardiometabolic and hematological traits ( 27668658) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		9 interacting genes: C3orf52 EPOR GFI1B HOXA1 HSPB1 RNF43 RSPO1 RSPO3 UBE2N	72 interacting genes: ACTN1 AGRN AJUBA ANKS3 ATXN2 BABAM2 BECN1 BEGAIN BEND5 BRCA1 CCDC136 CCDC85B CENPB COPS5 CPAP DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GPAT4 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 POLR1H PSMA3 RAB11FIP4 RCHY1 RCOR1 RINT1 RNF31 RUNDC3A TAF1 TLE5 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRF3
Entrez ID		84133	8328
HPRD ID		11737	05088
Ensembl ID		ENSG00000183579	ENSG00000165702
Uniprot IDs		Q9ULT6	A0A024R8F3 Q5VTD9
PDB IDs		8G4Y 8XFP 8XFS 8XFT 8Y69
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Erythropoietin Receptor Activity Semicircular Canal Formation Negative Regulation Of Protein Kinase C Signaling Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Frizzled Binding Abducens Nerve Formation Optokinetic Behavior Wnt Receptor Catabolic Process Ubiquitin Binding Positive Regulation Of Canonical Wnt Signaling Pathway Protein Kinase C Inhibitor Activity UBC13-MMS2 Complex	Calcium Ion Binding Regulation Of Cell Communication Regulation Of Signaling Elastic Fiber Regulation Of Signal Transduction Extracellular Matrix Structural Constituent Elastic Fiber Assembly Transcription Coactivator Activity Integrin Binding Embryo Implantation Basement Membrane Auditory Receptor Cell Fate Commitment Protein Kinase C Binding Extracellular Matrix Negative Regulation Of Cell Communication Negative Regulation Of Signaling Focal Adhesion Assembly Regulation Of Growth Protein Binding Developmental Process Extracellular Matrix Assembly Nuclear Ubiquitin Ligase Complex Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic G2 DNA Damage Checkpoint Signaling Stress Fiber BRCA1-A Complex Cell-substrate Junction Assembly Protein Modification By Small Protein Conjugation Cell-substrate Junction Organization Negative Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Negative Regulation Of Wnt Signaling Pathway Cytoplasm Identical Protein Binding Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Cell Population Proliferation Neuronal Ion Channel Clustering Astral Microtubule Organization Regulation Of Programmed Cell Death Protein Ubiquitination Vascular Associated Smooth Muscle Cell Development
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