ZNRF3 and GFI1B

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNRF3	GFI1B
Gene Name		zinc and ring finger 3	growth factor independent 1B transcription repressor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Transcription Factor Complex Nuclear Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Ligase Activity	RNA Polymerase II Transcription Factor Binding DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Wnt Receptor Catabolic Process Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Chromatin Modification Hemopoiesis Regulation Of Histone H3-K4 Methylation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Waist-hip ratio ( 20935629)
Protein-Protein Interactions		3 interactors: GFI1B RSPO1 UBE2N	71 interactors: ACTN1 AES AGPAT6 AGRN AJUBA ANKS3 ATXN2 BECN1 BEGAIN BEND5 BRCA1 BRE CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRD1 ZNRF3
Entrez ID		84133	8328
HPRD ID		11737	05088
Ensembl ID		ENSG00000183579	ENSG00000165702
Uniprot IDs		Q9ULT6	Q5VTD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Histone Modification Regulation Of Chromosome Organization Regulation Of Male Germ Cell Proliferation Regulation Of Histone Ubiquitination Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Double-strand Break Processing Positive Regulation Of Non-canonical Wnt Signaling Pathway Chromatin Modification Organelle Organization Postreplication Repair Chromatin Organization Regulation Of Histone H3-K4 Methylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Receptor Internalization Protein K63-linked Ubiquitination Positive Regulation Of Protein Modification Process DNA Catabolic Process, Exonucleolytic Regulation Of Organelle Organization Histone Ubiquitination Positive Regulation Of DNA Repair Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Chromosome Organization Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Histone Methylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Male Meiosis Positive Regulation Of Protein Metabolic Process Regulation Of DNA Repair Positive Regulation Of Signal Transduction Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Ubiquitin-protein Transferase Activity Canonical Wnt Signaling Pathway	Regulation Of Cellular Process Cell Communication Regulation Of Cellular Component Organization Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Signaling Cellular Response To Stimulus Signal Transduction Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Growth Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Canonical Wnt Signaling Pathway Developmental Process Secretion Negative Regulation Of Signaling Regulation Of Locomotion Cellular Process Regulation Of Cellular Component Movement Focal Adhesion Assembly Protein Localization Protein Ubiquitination Cellular Localization Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Cell-substrate Adhesion Adherens Junction Assembly Cell Differentiation Cellular Component Assembly Neurogenesis Auditory Receptor Cell Fate Commitment Anatomical Structure Development Regulation Of Gene Expression Regulation Of Proteolysis Regulation Of Apoptotic Process Cell-substrate Junction Assembly Regulation Of I-kappaB Kinase/NF-kappaB Signaling Secretion By Cell Regulation Of Cell Proliferation Receptor Clustering Regulation Of Vesicle-mediated Transport
Tagcloud ?		22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely kremen1 mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely kremen1 mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?