RSPO1 and ZNRF3

Number of citations of the paper that reports this interaction (PMID 24165923)
3

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RSPO1	ZNRF3
Gene Name		R-spondin 1	zinc and ring finger 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Heparin Binding	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Male Meiosis Regulation Of Gene Expression Positive Regulation Of Wnt Signaling Pathway Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Male Germ Cell Proliferation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Wnt Receptor Catabolic Process Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS			Waist-hip ratio ( 20935629)
Protein-Protein Interactions		2 interactors: RNF43 ZNRF3	3 interactors: GFI1B RSPO1 UBE2N
Entrez ID		284654	84133
HPRD ID		08288	11737
Ensembl ID		ENSG00000169218	ENSG00000183579
Uniprot IDs		Q2MKA7	Q9ULT6
PDB IDs		4BSO 4BSP 4BSR 4BSS 4BST 4BSU 4KNG 4KT1 4LI2
Enriched GO Terms of Interacting Partners?		Wnt Receptor Catabolic Process Receptor Catabolic Process Receptor Metabolic Process Stem Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Cell Proliferation Negative Regulation Of Non-canonical Wnt Signaling Pathway Cellular Macromolecule Catabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Non-canonical Wnt Signaling Pathway Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Catabolic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Organ Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process	Regulation Of Histone Modification Regulation Of Chromosome Organization Regulation Of Male Germ Cell Proliferation Regulation Of Histone Ubiquitination Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Double-strand Break Processing Positive Regulation Of Non-canonical Wnt Signaling Pathway Chromatin Modification Organelle Organization Postreplication Repair Chromatin Organization Regulation Of Histone H3-K4 Methylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Receptor Internalization Protein K63-linked Ubiquitination Positive Regulation Of Protein Modification Process DNA Catabolic Process, Exonucleolytic Regulation Of Organelle Organization Histone Ubiquitination Positive Regulation Of DNA Repair Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Chromosome Organization Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Histone Methylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Male Meiosis Positive Regulation Of Protein Metabolic Process Regulation Of DNA Repair Positive Regulation Of Signal Transduction Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Ubiquitin-protein Transferase Activity Canonical Wnt Signaling Pathway
Tagcloud ?			22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely kremen1 mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize
Tagcloud (Difference) ?			22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely kremen1 mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize
Tagcloud (Intersection) ?