ZNRF3 and RNF43

Number of citations of the paper that reports this interaction (PubMedID 37011906)
67

Data Source:
BioGRID (pull down)

		ZNRF3	RNF43
Description		zinc and ring finger 3	ring finger protein 43
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Limb Development Regulation Of Canonical Wnt Signaling Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Stem Cell Proliferation
Pathways		Regulation of FZD by ubiquitination	Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		A body shape index ( 34021172) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Diastolic blood pressure ( 30487518 27618448) Gut microbiota (bacterial taxa) ( 27694959) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448 30487518 29403010) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 25086665 29422604) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418 27618448) Type 2 diabetes ( 32499647) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412) White blood cell count ( 32888494)	Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Hemoglobin levels ( 32327693) Iron status biomarkers (ferritin levels) ( 33536631) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Pancreatic cancer ( 20686608) Prostate cancer ( 29892016) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Interacting Genes		9 interacting genes: C3orf52 EPOR GFI1B HOXA1 HSPB1 RNF43 RSPO1 RSPO3 UBE2N	9 interacting genes: EPOR UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N ZNRF3
Entrez ID		84133	54894
HPRD ID		11737	07896
Ensembl ID		ENSG00000183579	ENSG00000108375
Uniprot IDs		Q9ULT6	J3KSE3 Q68DV7
PDB IDs		8G4Y 8XFP 8XFS 8XFT 8Y69	4KNG 8WVU
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Erythropoietin Receptor Activity Semicircular Canal Formation Negative Regulation Of Protein Kinase C Signaling Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Frizzled Binding Abducens Nerve Formation Optokinetic Behavior Wnt Receptor Catabolic Process Ubiquitin Binding Positive Regulation Of Canonical Wnt Signaling Pathway Protein Kinase C Inhibitor Activity UBC13-MMS2 Complex	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Protein Modification Process Transferase Activity Catabolic Process Protein Metabolic Process Protein K11-linked Ubiquitination ATP Binding Nucleotide Binding Protein K63-linked Ubiquitination Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Regulation Of Non-canonical Wnt Signaling Pathway Protein K6-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process Erythropoietin Receptor Activity Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination TOR Signaling Wnt Receptor Catabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex UBC13-MMS2 Complex Regulation Of BMP Signaling Pathway Nucleoplasm Negative Regulation Of Cellular Response To Growth Factor Stimulus ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Post-translational Protein Modification
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