ZNRF3

Gene Name		zinc and ring finger 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Wnt Receptor Catabolic Process Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Waist-hip ratio ( 20935629)
Protein-protein Interactions		3 interactors: GFI1B RSPO1 UBE2N
Entrez ID		84133
HPRD ID		11737
Ensembl ID		ENSG00000183579
Uniprot IDs		Q9ULT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Histone Modification Regulation Of Chromosome Organization Regulation Of Male Germ Cell Proliferation Regulation Of Histone Ubiquitination Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Double-strand Break Processing Positive Regulation Of Non-canonical Wnt Signaling Pathway Chromatin Modification Organelle Organization Postreplication Repair Chromatin Organization Regulation Of Histone H3-K4 Methylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Receptor Internalization Protein K63-linked Ubiquitination Positive Regulation Of Protein Modification Process DNA Catabolic Process, Exonucleolytic Regulation Of Organelle Organization Histone Ubiquitination Positive Regulation Of DNA Repair Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Chromosome Organization Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Histone Methylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Male Meiosis Positive Regulation Of Protein Metabolic Process Regulation Of DNA Repair Positive Regulation Of Signal Transduction Positive Regulation Of Response To DNA Damage Stimulus Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Ubiquitin-protein Transferase Activity Canonical Wnt Signaling Pathway
Tagcloud ?		22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely kremen1 mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize