VPS45 and SNTG1

Number of citations of the paper that reports this interaction (PubMedID 11062261)
57

Data Source:
BioGRID (pull down)

		VPS45	SNTG1
Description		vacuolar protein sorting 45 homolog	syntrophin gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle	Nucleus Cytoplasm Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Ruffle Membrane
	Molecular Function	Protein Binding	Actin Binding Structural Molecule Activity Protein Binding
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport	Cell Communication
Pathways		Intra-Golgi traffic SARS-CoV-2 modulates autophagy Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hip circumference adjusted for BMI ( 34021172) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)	Abstraction and mental flexibility ( 31596458) Age at first sexual intercourse ( 34211149) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Interleukin-6 levels ( 22205395) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Pulmonary function ( 17903307) Pulse pressure ( 27841878) Remission after SSRI treatment in MDD or openness ( 29559929) Response to SSRI in MDD or openness ( 29559929) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		13 interacting genes: BCAR3 CASP8 IGF1R PAX2 PTPN1 RB1CC1 RBSN SNCA SNTG1 STX16 USP25 VPS11 VPS18	16 interacting genes: ADRA1D DGKZ DMD DTNA DTNB FGF2 KCNA4 PLEKHA1 PLEKHA2 SNAP23 STXBP3 TGFBR1 UBC VANGL2 VPS45 VTN
Entrez ID		11311	54212
HPRD ID		10301	16373
Ensembl ID		ENSG00000136631	ENSG00000147481
Uniprot IDs		A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7	A0A2R8Y5T2 A0A2R8Y631 B2RA84 Q9NSN8
PDB IDs			7PC7 7PC8 7QQN
Enriched GO Terms of Interacting Partners?		Regulation Of SNARE Complex Assembly Vesicle-mediated Transport Syntaxin Binding CORVET Complex Vacuole Organization Vesicle Docking Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Organelle Localization By Membrane Tethering Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Membrane Docking Endosomal Vesicle Fusion Synaptic Vesicle Priming Vesicle Fusion Organelle Membrane Fusion Negative Regulation Of Programmed Cell Death Insulin Receptor Binding Lysosomal Transport Early Endosome Organelle Fusion Synaptic Vesicle Synaptic Vesicle Membrane Regulation Of JNK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Membrane Fusion Negative Regulation Of Intracellular Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Response To Fibroblast Growth Factor Trans-Golgi Network To Recycling Endosome Transport Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribophagy Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Transport Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Organelle Localization Negative Regulation Of Response To Endoplasmic Reticulum Stress Lysosome Regulation Of Signal Transduction Cellular Response To Glucose Stimulus	Angiogenesis Involved In Coronary Vascular Morphogenesis Plasma Membrane PDZ Domain Binding Wound Healing Specific Granule Membrane Cell-cell Signaling Signaling Cell Communication Phosphatidylinositol-3,4-bisphosphate Binding Alpha1-adrenergic Receptor Activity Striated Muscle Contraction Lateral Plasma Membrane Animal Organ Development Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Endothelial Cell Proliferation Regulation Of Animal Organ Morphogenesis Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Wound Healing Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Tube Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Retinal Cell Programmed Cell Death Cell Migration Animal Organ Morphogenesis Response To Wounding Lymphatic Endothelial Cell Migration Regulation Of Heart Growth Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Endothelial Cell Migration Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Cell Motility Positive Regulation Of Stem Cell Proliferation Corticotropin Hormone Secreting Cell Differentiation Syntaxin Binding Tertiary Granule Muscle Tissue Morphogenesis Post-embryonic Development Roof Of Mouth Development Proepicardium Development Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Symbiont-containing Vacuole Smooth Muscle Cell-matrix Adhesion Rough Endoplasmic Reticulum Lumen
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