ATG13 and OTOS

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		ATG13	OTOS
Description		autophagy related 13	otospiralin
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Membrane Cytosol Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex	Extracellular Region
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity	Protein Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Regulation Of Cell Population Proliferation Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion	Sensory Perception Of Sound
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)	Gut microbiota (bacterial taxa) ( 27694959) Tinnitus in cisplatin-treated testicular cancer ( 30952644)
Interacting Genes		13 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C OTOS RNF31 SMCR8 ULK1	7 interacting genes: ATG13 CCDC125 CYSRT1 GNMT NGB RAB2A VAC14
Entrez ID		9776	150677
HPRD ID		13809	09714
Ensembl ID		ENSG00000175224	ENSG00000178602
Uniprot IDs		A8K0S6 O75143	Q8NHW6
PDB IDs		3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN 8DO8 8SOI 8SQZ 8SRM 9C82
Enriched GO Terms of Interacting Partners?		Mitophagy Autophagosome Membrane Autophagosome Organization Autophagosome Assembly Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Autophagosome Autophagy Vacuole Organization Autophagosome Maturation Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Cellular Response To Starvation Phospholipid Binding Organelle Assembly Response To Nutrient Levels Ubiquitin Protein Ligase Binding Atg1/ULK1 Kinase Complex Cytoplasmic Vesicle Catabolic Process Protein-containing Complex Organization GABA Receptor Binding Cellular Component Assembly Phagophore Assembly Site Positive Regulation Of Catabolic Process Microtubule Beta-tubulin Binding Cellular Response To Stress Organelle Membrane Regulation Of Autophagy Response To Stress Positive Regulation Of Autophagy Regulation Of Macroautophagy Organelle Organization Microtubule Binding Endomembrane System Positive Regulation Of Macroautophagy Response To Lead Ion Axoneme Cytosol Phagophore Assembly Site Membrane Cellular Response To Copper Ion Cytoplasm Response To Copper Ion GTPase Binding Regulation Of Autophagosome Assembly Amyloid-beta Complex
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