FBXO6 and ORC4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FBXO6	ORC4
Gene Name		F-box protein 6	origin recognition complex, subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm SCF Ubiquitin Ligase Complex	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Actin Cytoskeleton
	Molecular Function	Glycoprotein Binding Ubiquitin-protein Transferase Activity Protein Binding Carbohydrate Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	DNA Damage Checkpoint DNA Repair Proteolysis Glycoprotein Catabolic Process Response To Unfolded Protein Protein Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Protein folding Antigen processing: Ubiquitination & Proteasome degradation Chaperonin-mediated protein folding Association of TriC/CCT with target proteins during biosynthesis Class I MHC mediated antigen processing & presentation Adaptive Immune System	G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ORC4 SKP1	27 interactors: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 HIST3H3 HIST4H4 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RPA2 RRM2B TCF4
Entrez ID		26270	5000
HPRD ID		07291	09118
Ensembl ID		ENSG00000116663	ENSG00000115947
Uniprot IDs		Q9NRD1	A8K7H4 O43929 Q96B14
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Histone H2A Monoubiquitination Mitotic Cell Cycle Histone H2A Ubiquitination Histone Monoubiquitination Cell Cycle Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process DNA Replication Initiation Histone Ubiquitination Cell Cycle Protein Monoubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA-dependent DNA Replication G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Circadian Rhythm	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication DNA Replication DNA Replication Initiation Cell Cycle Process Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Nitrogen Compound Metabolic Process Chromosome Organization DNA Unwinding Involved In DNA Replication Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process DNA Conformation Change DNA Duplex Unwinding DNA Geometric Change Biosynthetic Process Organelle Organization Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Protein-DNA Complex Assembly Cellular Response To DNA Damage Stimulus Regulation Of DNA Recombination Telomere Maintenance Regulation Of Mitotic Cell Cycle Phase Transition Cell Proliferation Regulation Of Cell Cycle Phase Transition SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Cell Cycle Chromatin Assembly Cellular Process Cellular Macromolecular Complex Assembly Response To Epidermal Growth Factor Regulation Of Protein Export From Nucleus Chromatin Assembly Or Disassembly
Tagcloud ?		ablated abolished almost attenuating bip cadmium chop elevation endoplasmic entirely er erad functioning hek293 inhibiting inhibition jnk1 jun ligase markedly precise reticulum sensitivity stress subsequent substrate thereby ubiquitin unexplored	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Difference) ?		ablated abolished almost attenuating bip cadmium chop elevation endoplasmic entirely er erad functioning hek293 inhibiting inhibition jnk1 jun ligase markedly precise reticulum sensitivity stress subsequent substrate thereby ubiquitin unexplored	archaeon cctb chec2 dpsa elfa fumc gapb halobacterium halophilic imd2 ipg msra nrc ppia rphs6 rpl18e rpl31eand rps27ae shsp thic thid tpia trh5 uvrc vng0683c vng1300h vng1807h vng6254 yufn
Tagcloud (Intersection) ?