BOLL and CBX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BOLL	CBX2
Description		boule RNA binding protein	chromobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome PcG Protein Complex PRC1 Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Activator Activity Identical Protein Binding	DNA Binding Chromatin Binding Protein Binding Histone H3K9me2/3 Reader Activity
	Biological Process	Regulation Of Translation Spermatogenesis Cell Differentiation Positive Regulation Of Translational Initiation Meiotic Cell Cycle 3'-UTR-mediated MRNA Stabilization	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Sex Differentiation Cell Differentiation Development Of Primary Sexual Characteristics
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Idiopathic dilated cardiomyopathy ( 29495422) Intracranial aneurysm ( 18997786) Morning person ( 30696823) Rheumatoid arthritis ( 32868391) Schizophrenia ( 29483656 25056061) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		37 interacting genes: AGRN ARID5A ATXN2L C1orf94 CBX2 DAZ1 DAZ4 DCANP1 EHHADH FAM168A FOXD4L1 HNRNPLL HYAL3 HYPK INO80B KRTAP19-3 NAF1 NPBWR2 PATZ1 PHF1 POGZ POM121 PRR34 RBFOX2 RBPMS RBPMS2 RHOXF2 SEMA3B SERF2 SNRPC SPMIP2 SYCE1L TCEA2 TFG ZBTB32 ZC3H10 ZNF385C	25 interacting genes: BOLL CYSRT1 DHX57 H3-3A H3-4 H3C1 H3C14 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RYBP TRIM55 TRIM63
Entrez ID		66037	84733
HPRD ID		07314	14397
Ensembl ID		ENSG00000152430	ENSG00000173894
Uniprot IDs		Q8N9W6	Q14781
PDB IDs			2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding MRNA Binding Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Binding Nucleus Translation Activator Activity Regulation Of Alternative MRNA Splicing, Via Spliceosome	Keratin Filament Intermediate Filament Structural Constituent Of Chromatin Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Nucleosome Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleosome Positive Regulation Of RNA Splicing Nucleosome Organization Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Protein-DNA Complex Assembly Hair Cycle Identical Protein Binding Positive Regulation Of MRNA Metabolic Process Protein Heterodimerization Activity Chromatin Remodeling Spliceosomal Complex
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