ANKRD29 and GTF2H5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ANKRD29	GTF2H5
Description		ankyrin repeat domain 29	general transcription factor IIH subunit 5
Image		No pdb structure
GO Annotations	Cellular Component		Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Nucleolus Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) DNA Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA Damage Response Cellular Response To Gamma Radiation
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24256812)	Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin levels ( 29678681) Systemic sclerosis ( 29293537)
Interacting Genes		10 interacting genes: CABP2 CRACR2A FAM90A1 FERMT3 GTF2H5 GYPA HLCS MRPL53 RABGEF1 USP32	8 interacting genes: ANKRD29 CDK7 ERCC3 GSC2 GTF2E1 GTF2H2 INCA1 NGRN
Entrez ID		147463	404672
HPRD ID		12464	10581
Ensembl ID		ENSG00000154065	ENSG00000272047
Uniprot IDs		Q8N6D5	Q6ZYL4
PDB IDs			1YDL 2JNJ 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4 7AD8 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVV 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?			Transcription Initiation At RNA Polymerase II Promoter Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex DNA-templated Transcription Initiation Transcription Factor TFIID Complex Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Activity Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Nucleotide-excision Repair Nucleobase-containing Compound Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIE Complex DNA Repair Transcription Factor TFIIK Complex Core TFIIH Complex Portion Of Holo TFIIH Complex CAK-ERCC2 Complex Transcription Pausing By RNA Polymerase II RNA Metabolic Process Response To UV Nucleoplasm Macromolecule Biosynthetic Process Mitochondrial Ribosome Assembly RNA Polymerase II Promoter Clearance DNA Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity DNA Damage Response SnRNA Transcription By RNA Polymerase II DNA Topological Change Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleus Negative Regulation Of Cyclin-dependent Protein Kinase Activity UV Protection Transcription-coupled Nucleotide-excision Repair 3'-5' DNA Helicase Activity Transcription Preinitiation Complex Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity SnRNA Transcription G Protein-coupled Receptor Internalization Positive Regulation Of Mitochondrial Translation DNA Conformation Change Nucleic Acid Metabolic Process Response To Light Stimulus Regulation Of Mitochondrial Translation Ribosome Assembly
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