ANKRD29 and FERMT3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ANKRD29	FERMT3
Name		ankyrin repeat domain 29	FERM domain containing kindlin 3
Structure		No pdb structure
GO Annotations	Cellular Component	None	Podosome Extracellular Region Membrane Cell-substrate Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Integrin Binding Protein Binding Lipid Binding
	Biological Process	None	Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation
Pathways		None	Platelet degranulation
Diseases		None	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24256812 )	Attention deficit hyperactivity disorder ( 21784300 ) Crohn's disease ( 28067908 ) Fruit consumption ( 32066663 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean platelet volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 )
Interacting Genes		10 interacting genes: CABP2 CRACR2A FAM90A1 FERMT3 GTF2H5 GYPA HLCS MRPL53 RABGEF1 USP32	11 interacting genes: ANKRD29 APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA PRPF18 TINF2 TRIM15
Entrez ID		147463	83706
HPRD ID		12464	07440
Ensembl ID		ENSG00000154065	ENSG00000149781
Uniprot IDs		Q8N6D5	F5H3I6 Q86UX7
PDB IDs		Not available	2YS3 6V97 6V9G 7C3M
GO Terms Enriched among Interactors		None	Anchoring Junction Focal Adhesion Regulation Of Spontaneous Synaptic Transmission Integrin Binding Cell Adhesion Regulation Of Neurotransmitter Uptake Cell-substrate Adhesion Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cell-cell Adhesion Heterotypic Cell-cell Adhesion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Positive Regulation Of Intracellular Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substrate Adhesion-dependent Cell Spreading Myoblast Fate Specification Integrin Alpha7-beta1 Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex Visual Behavior Glial Cell Development Synaptic Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process