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HIST1H4F and PAK2
Number of citations of the paper that reports this interaction (PMID
21724829
)
10
Data Source:
BioGRID
(enzymatic study)
HIST1H4F
PAK2
Gene Name
histone cluster 1, H4f
p21 protein (Cdc42/Rac)-activated kinase 2
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Identical Protein Binding
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Mitotic Cell Cycle
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Signal Transduction
Axon Guidance
Viral Process
Phosphorylation
Peptidyl-serine Phosphorylation
Signal Transduction By Phosphorylation
T Cell Costimulation
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Growth
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Costimulation by the CD28 family
Axon guidance
HIV Infection
FCERI mediated MAPK activation
VEGFA-VEGFR2 Pathway
Nef and signal transduction
Ephrin signaling
Activation of Rac
VEGFR2 mediated vascular permeability
Programmed Cell Death
EPH-Ephrin signaling
Innate Immune System
Generation of second messenger molecules
Semaphorin interactions
Apoptotic execution phase
CD28 co-stimulation
Regulation of activated PAK-2p34 by proteasome mediated degradation
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
CD28 dependent Vav1 pathway
Stimulation of the cell death response by PAK-2p34
TCR signaling
Signaling by VEGF
Sema3A PAK dependent Axon repulsion
Fc epsilon receptor (FCERI) signaling
Signaling by Robo receptor
Regulation of Apoptosis
Adaptive Immune System
Drugs
Diseases
GWAS
Total ventricular volume (
21116278
)
Protein-Protein Interactions
9 interactors:
ASF1A
ASF1B
CENPA
DAXX
PAK2
PRMT6
SMARCA4
TBL1XR1
UCHL5
51 interactors:
ABI1
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
DOCK2
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
HCK
HIST1H4F
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
PACSIN3
RAC1
RAC2
RAF1
RHOJ
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
8361
5062
HPRD ID
11915
05428
Ensembl ID
ENSG00000180370
Uniprot IDs
B2R4R0
P62805
A8K5M4
Q13177
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
3PCS
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromatin Organization
Nucleosome Organization
Chromatin Assembly Or Disassembly
Chromosome Organization
Nucleosome Assembly
Chromatin Assembly
DNA Replication-independent Nucleosome Assembly
Protein-DNA Complex Assembly
DNA Packaging
DNA Conformation Change
Transcription, DNA-templated
RNA Biosynthetic Process
DNA Replication-dependent Nucleosome Assembly
Organelle Organization
RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Viral Process
Chromatin Remodeling
Gene Expression
Cellular Macromolecule Biosynthetic Process
Cellular Macromolecular Complex Assembly
Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
ATP-dependent Chromatin Remodeling
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Histone Modification
Biosynthetic Process
Protein Complex Assembly
Regulation Of Gene Expression
DNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Histone H3-R2 Methylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis
Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
DNA Repair
Positive Regulation Of Cellular Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Endocytosis
Movement Of Cell Or Subcellular Component
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Axon Guidance
Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Locomotion
Cytoskeleton Organization
Chemotaxis
Phagocytosis
Axonogenesis
Neurotrophin TRK Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Immune Response-regulating Signaling Pathway
ERBB Signaling Pathway
Axon Development
Cellular Response To Peptide Hormone Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Cellular Response To Peptide
Cell Projection Organization
Actin Filament-based Process
Neuron Projection Morphogenesis
Signal Transduction
Signaling
Response To Peptide Hormone
Peptidyl-tyrosine Autophosphorylation
Cell Communication
Innate Immune Response
Cellular Response To Organonitrogen Compound
Cell Development
Cellular Response To Growth Factor Stimulus
Apoptotic Process
Response To Peptide
Intracellular Signal Transduction
Actin Cytoskeleton Organization
Cell Projection Morphogenesis
Regulation Of Immune System Process
Cellular Response To Organic Substance
Response To Growth Factor
Cell Part Morphogenesis
Programmed Cell Death
Tagcloud
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pakl
phenomena
probed
proliferate
proto
raf1
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Difference)
?
cot
densitometry
erk2
hog
immunoreactivities
jnks
kinases
mapkapk2
mapks
mek1
mekkl
mkk3
mlk3
mos
myocytes
pakl
phenomena
probed
proliferate
proto
raf1
rafb
resist
rsk1
rsk2
sekl
tpl
ventricle
ventricles
Tagcloud (Intersection)
?