GOLGA3 and TCF7

Data Source: HiPPIP (Novel)

		GOLGA3	TCF7
Name		golgin A3	transcription factor 7
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane	Chromatin Nucleus Nucleoplasm Nuclear Body Beta-catenin-TCF Complex
	Molecular Function	Protein Binding Cadherin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA Binding Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	None	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response Wnt Signaling Pathway Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of DNA-templated Transcription Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4
Pathways		RND2 GTPase cycle	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling Germ layer formation at gastrulation Formation of axial mesoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription
GWAS		Basal metabolic rate ( 31453325 ) Basal metabolic rate variance ( 31453325 ) Body mass index ( 28552196 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Refractive error ( 32231278 ) Smoking initiation ( 33082346 )	Autoimmune thyroid disease ( 32581359 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Menarche (age at onset) ( 25231870 ) Multiple sclerosis ( 21833088 24076602 31604244 ) Rheumatoid arthritis ( 32868391 ) Sum eosinophil basophil counts ( 27863252 ) Systemic lupus erythematosus ( 26502338 27399966 28714469 33272962 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Novel Interactors		6 novel interactors: DEAF1 MPI PXMP2 TCF7 ZNF10 ZNF26	2 novel interactors: GOLGA3 JADE2
Interacting Genes		10 interacting genes: ATXN7 CASP2 CASP3 CASP7 FXR1 GOLGA7 GOPC KCNJ1 OLIG2 TSNAX	3 interacting genes: NHERF2 SS18L1 UCHL5
Entrez ID		2802	6932
HPRD ID		03990	01797
Ensembl ID		ENSG00000090615	ENSG00000081059
Uniprot IDs		A0A8I5KWY9 Q08378	B3KQ75 P36402
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Execution Phase Of Apoptosis Cellular Response To Staurosporine Luteolysis Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Protein Poly-ADP-ribosylation Aspartic-type Endopeptidase Activity Cysteine-type Peptidase Activity Ovulation Cycle Process Protein Processing Cellular Response To Alkaloid Leukocyte Apoptotic Process Pyroptotic Inflammatory Response Mannose To Fructose-6-phosphate Catabolic Process Mannose-6-phosphate Isomerase Activity Negative Regulation Of Anion Channel Activity	None