GOLGA3 and CASP2

Number of citations of the paper that reports this interaction (PMID 10791974)
75

Data Source:
HPRD (in vitro, in vivo)

		GOLGA3	CASP2
Gene Name		golgin A3	caspase 2, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Membrane Golgi Transport Complex Golgi Cisterna Membrane Extrinsic Component Of Golgi Membrane	Nucleus Cytoplasm Mitochondrion Cytosol Membrane
	Molecular Function	Transporter Activity Protein Binding	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
	Biological Process	Intra-Golgi Vesicle-mediated Transport	Luteolysis Neural Retina Development Proteolysis Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways			Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway p75 NTR receptor-mediated signalling NADE modulates death signalling Innate Immune System
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22542470)
Protein-Protein Interactions		8 interactors: ATXN7 CASP2 CASP3 CASP7 GOLGA7 GOPC KCNJ1 TSNAX	30 interactors: ADCYAP1 BID BIRC2 CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I
Entrez ID		2802	835
HPRD ID		03990	02800
Ensembl ID		ENSG00000090615	ENSG00000106144
Uniprot IDs		Q08378	C9JRR9 D3DXD8 D3DXD9 P42575
PDB IDs			1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM
Enriched GO Terms of Interacting Partners?		Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Golgi To Plasma Membrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Neuron Death Cytoplasmic Sequestering Of CFTR Protein Regulation Of G-protein Activated Inward Rectifier Potassium Channel Activity Post-Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleus Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Death Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Peptidase Activity Regulation Of Proteolysis Renal Sodium Ion Absorption Renal Sodium Ion Transport Luteolysis Peptidyl-L-cysteine S-palmitoylation Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Glial Cell Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Regulation Of Neuron Apoptotic Process Regulation Of Golgi To Plasma Membrane Protein Transport Apoptotic Process Golgi Vesicle Transport Programmed Cell Death Reproduction Regulation Of Neuron Death	Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Metabolic Process Response To Stress Signaling Positive Regulation Of Catalytic Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Signal Transduction Viral Process Cell Communication Positive Regulation Of Hydrolase Activity Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Execution Phase Of Apoptosis Positive Regulation Of Cell Death Response To Stimulus Glial Cell Apoptotic Process Protein Metabolic Process Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Intracellular Signal Transduction Regulation Of Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Tagcloud ?			amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized
Tagcloud (Difference) ?			amplified array athymic caspase counterparts delayed e1a emu enhances extended lymphoma maintenance mammary mmtv mycn neu neuroblastoma nude observations oncogene paraspinal predominantly ras subset surprisingly th thoracic tumorigenesis vascularized
Tagcloud (Intersection) ?