H2BC8 and UBR2

Number of citations of the paper that reports this interaction (PubMedID 22616001)
61

Data Source:
BioGRID (enzymatic study)

		H2BC8	UBR2
Description		H2B clustered histone 8	ubiquitin protein ligase E3 component n-recognin 2
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GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Chromatin Nucleus Chromosome Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Identical Protein Binding Protein Heterodimerization Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding Histone H2A Ubiquitin Ligase Activity
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Ubiquitin-dependent Protein Catabolic Process Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Transposable Element Silencing Protein Ubiquitination Protein Catabolic Process Heterochromatin Formation Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper
Diseases
GWAS			HDL cholesterol levels in HIV infection ( 33109212) Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein levels ( 29403010)
Interacting Genes		7 interacting genes: AP2M1 ESR1 PTMA RAD51B TGM2 UBR2 YWHAQ	11 interacting genes: ATF3 CRYAA H2AC20 H2BC8 NTAN1 NTAQ1 PKN1 SUOX UBE2B UBE2D2 UBE2H
Entrez ID		8339	23304
HPRD ID		11897	09853
Ensembl ID		ENSG00000273802	ENSG00000024048
Uniprot IDs		B2R4S9 P62807	B3KXG6 Q8IWV8
PDB IDs		5GT0 5KGF 6ACO 6C0W 6FML 6R0C 6RNY 6SE0 6SE6 6SEE 6SEF 6SEG 6UPK 6UPL 6X59 6X5A 6XJD 7A08 7JO9 7JOA 7PII 7R5R 7TAN 7TRF 7U46 7U47 7U4D 7U50 7U51 7U52 7U53 7UV9 7Y8R 7YWX 7YYH 8ATF 8AV6 8JBX 8OFF 8OO7 8OOA 8OOP 8OOS 8OX0 8OX1 8QZM 8TXV 8TXW 8TXX 8U13 8VWS 8VWT 8VWU 8VWV 8X15 8X19 8X1C 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM 9EOZ	3NY2 3NY3 5TDA 5TDB 5TDD 5UM3
Enriched GO Terms of Interacting Partners?		14-3-3 Protein Binding Reciprocal Meiotic Recombination Homologous Recombination Chromatin Organization Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Histone H2A Ubiquitin Ligase Activity Transmembrane Transporter Binding Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Morphogenesis Of A Branching Structure TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Morphogenesis Of A Branching Epithelium Positive Regulation Of Nitric-oxide Synthase Activity Chromatin Remodeling Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Rad51B-Rad51C-Rad51D-XRCC2 Complex Protein Deamination Cellular Response To Serotonin Salivary Gland Cavitation Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity Blastocyst Growth Dopamine Secretion Cellular Response To Dopamine Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein-glutamine Gamma-glutamyltransferase Activity L-leucine Binding Postsynaptic Neurotransmitter Receptor Internalization Nitric-oxide Synthase Regulator Activity Response To Dopamine Catecholamine Secretion Cellular Response To Oxygen-containing Compound Prostate Gland Growth Vagina Development	Protein-N-terminal Asparagine Amidohydrolase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Sulfite Oxidase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Protein Autoubiquitination CHOP-ATF3 Complex Protein Heterodimerization Activity Post-translational Protein Modification Chromatin Organization Positive Regulation Of Reciprocal Meiotic Recombination Structural Constituent Of Chromatin Histone H3T11 Kinase Activity Molybdenum Ion Binding Protein Modification Process Nucleosome Molybdopterin Cofactor Binding Macromolecule Catabolic Process HULC Complex
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