WNT7A

Description		Wnt family member 7A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity
	Biological Process	Embryonic Axis Specification Cartilage Condensation Angiogenesis Chondrocyte Differentiation Apoptotic Process Neurotransmitter Secretion Axonogenesis Synapse Assembly Sex Differentiation Positive Regulation Of Cell Population Proliferation Tissue Development Dorsal/ventral Pattern Formation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Cerebellar Granule Cell Differentiation Cell Proliferation In Forebrain Central Nervous System Vasculogenesis Establishment Of Cell Polarity Cell Differentiation Neuron Differentiation Embryonic Limb Morphogenesis Regulation Of Axon Diameter Response To Estradiol Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Non-canonical Wnt Signaling Pathway Synaptic Vesicle Recycling Regulation Of Cell Population Proliferation Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Response To Estrogen Cell Fate Commitment Asymmetric Protein Localization Involved In Cell Fate Determination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Somatic Stem Cell Division Animal Organ Development System Development Stem Cell Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Synapse Organization Cartilage Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Synapse Assembly Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Uterus Development Oviduct Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Establishment Of Blood-brain Barrier Dendritic Spine Morphogenesis Uterus Morphogenesis Secondary Palate Development Lens Fiber Cell Development Cellular Response To Transforming Growth Factor Beta Stimulus Presynapse Assembly Postsynapse Assembly Regulation Of Postsynapse Organization Excitatory Synapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Presynapse Assembly Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases		Al-Awadi/Raas-Rothschild syndrome; Ulna and fibula, absence of, with sever limb deficiency Fuhrmann syndrome; Fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly
GWAS		Body mass index ( 26426971) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 29124443 31152163) Glomerular filtration rate (creatinine) ( 26831199) Hematocrit ( 32888494) Pulse pressure ( 27841878 30578418) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Serum uric acid levels ( 29124443)
Interacting Genes		3 interacting genes: FZD5 FZD9 STRN4
Entrez ID		7476
HPRD ID		03341
Ensembl ID		ENSG00000154764
Uniprot IDs		O00755
PDB IDs		4UZQ 8TZO 8TZP
Enriched GO Terms of Interacting Partners?		Wnt Receptor Activity Wnt-protein Binding Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Wnt Signaling Pathway Transmembrane Signaling Receptor Activity Intestinal Epithelial Cell Maturation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Spemann Organizer Formation Post-embryonic Camera-type Eye Development Lymphocyte Differentiation Negative Regulation Of Receptor Clustering Bone Regeneration Regulation Of Chorionic Trophoblast Cell Proliferation Chorionic Trophoblast Cell Differentiation Leukocyte Differentiation Glandular Epithelial Cell Maturation Anterior/posterior Axis Specification, Embryo G Protein-coupled Receptor Activity Protein-containing Complex Binding Mononuclear Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Columnar/cuboidal Epithelial Cell Maturation Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Mitochondrial Depolarization Armadillo Repeat Domain Binding Dendrite Lymphocyte Activation Embryonic Camera-type Eye Development Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Modification Of Postsynaptic Structure Regulation Of Bicellular Tight Junction Assembly Regulation Of Cellular Component Organization Leukocyte Activation Labyrinthine Layer Blood Vessel Development Cell Activation Cell Surface Apoptotic Process Involved In Morphogenesis Epithelial Cell Maturation Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Mitochondrial Membrane Permeability Release Of Cytochrome C From Mitochondria Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Mitochondrial Depolarization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Receptor Clustering Negative Regulation Of Membrane Permeability
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