WNT7A and FZD5

Number of citations of the paper that reports this interaction (PMID 12857724)
25

Data Source:
HPRD (in vivo)

		WNT7A	FZD5
Gene Name		wingless-type MMTV integration site family, member 7A	frizzled class receptor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface	Golgi Membrane Plasma Membrane Tight Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Frizzled Binding Cytokine Activity Receptor Agonist Activity	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Embryonic Axis Specification Cartilage Condensation Angiogenesis Chondrocyte Differentiation Neurotransmitter Secretion Sex Differentiation Asymmetric Protein Localization Dorsal/ventral Pattern Formation Positive Regulation Of Endothelial Cell Migration Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Granule Cell Differentiation Cell Proliferation In Forebrain Central Nervous System Vasculogenesis Establishment Of Cell Polarity Neuron Differentiation Regulation Of Axon Diameter Response To Estradiol Somatic Stem Cell Maintenance Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Non-canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Wound Healing, Spreading Of Epidermal Cells Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Somatic Stem Cell Division Stem Cell Development Negative Regulation Of Neurogenesis Synapse Organization Positive Regulation Of Synapse Assembly Palate Development Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Oviduct Development Canonical Wnt Signaling Pathway Uterus Morphogenesis Lens Fiber Cell Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Embryonic Axis Specification Angiogenesis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Tight Junction Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		3 interactors: FZD5 FZD9 STRN4	11 interactors: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A
Entrez ID		7476	7855
HPRD ID		03341	03427
Ensembl ID			ENSG00000163251
Uniprot IDs		O00755	Q13467
PDB IDs
Enriched GO Terms of Interacting Partners?		Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Lymphocyte Differentiation Regulation Of Chorionic Trophoblast Cell Proliferation Spemann Organizer Formation Wnt Signaling Pathway Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Leukocyte Differentiation Lymphocyte Activation Chorionic Trophoblast Cell Differentiation Chorion Development Regulation Of Tight Junction Assembly Leukocyte Activation Post-embryonic Camera-type Eye Development Branching Involved In Labyrinthine Layer Morphogenesis Hemopoiesis Anterior/posterior Axis Specification, Embryo Cell Activation Immune System Development Labyrinthine Layer Morphogenesis Apoptotic Process Involved In Morphogenesis Dorsal/ventral Axis Specification Labyrinthine Layer Blood Vessel Development Apoptotic Process Involved In Development Embryonic Placenta Morphogenesis Cell Differentiation Involved In Embryonic Placenta Development Placenta Blood Vessel Development Developmental Programmed Cell Death Developmental Induction Positive Regulation Of Interferon-gamma Production Embryonic Axis Specification G-protein Coupled Receptor Signaling Pathway Neuroblast Proliferation Labyrinthine Layer Development Embryonic Camera-type Eye Development Regulation Of Cell Junction Assembly T Cell Differentiation In Thymus Anterior/posterior Axis Specification Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Regulation Of Interferon-gamma Production Stem Cell Proliferation Embryonic Pattern Specification Generation Of Neurons	Regulation Of Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Embryonic Development Non-canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Cartilage Development Pericardium Morphogenesis Epithelial To Mesenchymal Transition Genitalia Development Negative Regulation Of Signal Transduction Morphogenesis Of An Epithelial Sheet Connective Tissue Development Stem Cell Development Negative Regulation Of Signaling Regulation Of MAPK Cascade Single Organism Reproductive Process Embryonic Digit Morphogenesis Sex Differentiation Regulation Of Phosphorylation Somitogenesis Reproductive Process Developmental Process Involved In Reproduction Stem Cell Differentiation Embryonic Pattern Specification Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Somite Development Primitive Streak Formation Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorus Metabolic Process Palate Development Regulation Of Embryonic Development Axis Specification Segmentation Mesenchymal Cell Development Negative Regulation Of Phosphorylation Convergent Extension Positive Regulation Of Peptidyl-threonine Phosphorylation Uterus Development Mesenchymal Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Dopaminergic Neuron Differentiation Forebrain Development Central Nervous System Development
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt9a	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt9a	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Intersection) ?