WNT7A and FZD5

Number of citations of the paper that reports this interaction (PubMedID 12857724)
0

Data Source:
HPRD (in vivo)

		WNT7A	FZD5
Description		Wnt family member 7A	frizzled class receptor 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse	Golgi Membrane Early Endosome Golgi Apparatus Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Cell Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity Protein-containing Complex Binding
	Biological Process	Embryonic Axis Specification Cartilage Condensation Angiogenesis Chondrocyte Differentiation Apoptotic Process Neurotransmitter Secretion Axonogenesis Synapse Assembly Sex Differentiation Positive Regulation Of Cell Population Proliferation Tissue Development Dorsal/ventral Pattern Formation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Cerebellar Granule Cell Differentiation Cell Proliferation In Forebrain Central Nervous System Vasculogenesis Establishment Of Cell Polarity Cell Differentiation Neuron Differentiation Embryonic Limb Morphogenesis Regulation Of Axon Diameter Response To Estradiol Somatic Stem Cell Population Maintenance Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Non-canonical Wnt Signaling Pathway Synaptic Vesicle Recycling Regulation Of Cell Population Proliferation Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Response To Estrogen Cell Fate Commitment Asymmetric Protein Localization Involved In Cell Fate Determination Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Somatic Stem Cell Division Animal Organ Development System Development Stem Cell Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Synapse Organization Cartilage Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Synapse Assembly Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Uterus Development Oviduct Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Limb Development Establishment Of Blood-brain Barrier Dendritic Spine Morphogenesis Uterus Morphogenesis Secondary Palate Development Lens Fiber Cell Development Cellular Response To Transforming Growth Factor Beta Stimulus Presynapse Assembly Postsynapse Assembly Regulation Of Postsynapse Organization Excitatory Synapse Assembly Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Presynapse Assembly Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Embryonic Axis Specification Angiogenesis Eye Development Vasculature Development Glandular Epithelial Cell Maturation Positive Regulation Of T Cell Cytokine Production Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Wnt Signaling Pathway Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis System Development Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Intestinal Epithelial Cell Maturation Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Bicellular Tight Junction Assembly
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants
Drugs
Diseases		Al-Awadi/Raas-Rothschild syndrome; Ulna and fibula, absence of, with sever limb deficiency Fuhrmann syndrome; Fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly
GWAS		Body mass index ( 26426971) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 29124443 31152163) Glomerular filtration rate (creatinine) ( 26831199) Hematocrit ( 32888494) Pulse pressure ( 27841878 30578418) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Serum uric acid levels ( 29124443)	Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		3 interacting genes: FZD5 FZD9 STRN4	13 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A
Entrez ID		7476	7855
HPRD ID		03341	03427
Ensembl ID		ENSG00000154764	ENSG00000163251
Uniprot IDs		O00755	Q13467
PDB IDs		4UZQ 8TZO 8TZP	5URY 5URZ 6O39 6WW2
Enriched GO Terms of Interacting Partners?		Wnt Receptor Activity Wnt-protein Binding Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Wnt Signaling Pathway Transmembrane Signaling Receptor Activity Intestinal Epithelial Cell Maturation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Spemann Organizer Formation Post-embryonic Camera-type Eye Development Lymphocyte Differentiation Negative Regulation Of Receptor Clustering Bone Regeneration Regulation Of Chorionic Trophoblast Cell Proliferation Chorionic Trophoblast Cell Differentiation Leukocyte Differentiation Glandular Epithelial Cell Maturation Anterior/posterior Axis Specification, Embryo G Protein-coupled Receptor Activity Protein-containing Complex Binding Mononuclear Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Columnar/cuboidal Epithelial Cell Maturation Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Mitochondrial Depolarization Armadillo Repeat Domain Binding Dendrite Lymphocyte Activation Embryonic Camera-type Eye Development Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Modification Of Postsynaptic Structure Regulation Of Bicellular Tight Junction Assembly Regulation Of Cellular Component Organization Leukocyte Activation Labyrinthine Layer Blood Vessel Development Cell Activation Cell Surface Apoptotic Process Involved In Morphogenesis Epithelial Cell Maturation Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Mitochondrial Membrane Permeability Release Of Cytochrome C From Mitochondria Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Mitochondrial Depolarization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Receptor Clustering Negative Regulation Of Membrane Permeability	Canonical Wnt Signaling Pathway Postsynapse Assembly Wnt Signaling Pathway Frizzled Binding Positive Regulation Of Protein Localization To Synapse Toxin Transmembrane Transporter Activity Regulation Of Neuron Projection Development Wnt Signalosome Regulation Of Protein Localization To Cilium Epithelial To Mesenchymal Transition Midbrain Dopaminergic Neuron Differentiation Excitatory Synapse Assembly Secondary Palate Development Presynapse Assembly Establishment Of Cell Polarity Negative Regulation Of Developmental Process Mesenchymal Cell Differentiation Presynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Uterus Development Positive Regulation Of Cell Projection Organization Central Nervous System Neuron Differentiation Regulation Of Axonogenesis Regulation Of JNK Cascade Regulation Of Protein Localization To Synapse Wnt-protein Binding Positive Regulation Of Neuron Projection Development Establishment Or Maintenance Of Cell Polarity Embryonic Axis Specification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Lipid Midbrain Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Dopaminergic Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Neuron Projection Organization Regulation Of Protein Localization Postsynapse Organization Presynapse Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Receptor Tyrosine Kinase-like Orphan Receptor Binding Chemoattraction Of Serotonergic Neuron Axon
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