WNT3

Gene Name		wingless-type MMTV integration site family, member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane
	Molecular Function	Frizzled Binding Protein Binding Protein Domain Specific Binding Receptor Agonist Activity
	Biological Process	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Parkinson's disease ( 22451204 21812969)
Protein-protein Interactions		1 interactors: FZD1
Entrez ID		7473
HPRD ID		01318
Ensembl ID		ENSG00000108379
Uniprot IDs		P56703
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Involved In Osteoblast Differentiation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Autocrine Signaling Muscular Septum Morphogenesis Membranous Septum Morphogenesis Hard Palate Development Negative Regulation Of Catenin Import Into Nucleus Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Catenin Import Into Nucleus Non-canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of BMP Signaling Pathway Ventricular Septum Development Cardiac Septum Morphogenesis Outflow Tract Morphogenesis Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Negative Regulation Of Protein Import Into Nucleus Cardiac Septum Development Negative Regulation Of Protein Localization To Nucleus Regulation Of BMP Signaling Pathway Negative Regulation Of Intracellular Protein Transport Canonical Wnt Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Palate Development Cardiac Ventricle Development Regulation Of Embryonic Development Negative Regulation Of Intracellular Transport Positive Regulation Of Canonical Wnt Signaling Pathway Osteoblast Differentiation Cardiac Chamber Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Protein Import Into Nucleus Regulation Of Organ Morphogenesis Negative Regulation Of Protein Transport Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Protein Transport Wnt Signaling Pathway Muscle Organ Development Ossification Regulation Of Wnt Signaling Pathway Stem Cell Differentiation
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1