TRAPPC3 and CDC45

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TRAPPC3	CDC45
Gene Name		trafficking protein particle complex 3	cell division cycle 45
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex
	Molecular Function	Protein Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding 3'-5' DNA Helicase Activity
	Biological Process	Vesicle-mediated Transport	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of Chromatin Silencing At Telomere DNA Duplex Unwinding Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly
Pathways			E2F mediated regulation of DNA replication Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Activation of the pre-replicative complex S Phase DNA strand elongation Cell Cycle, Mitotic Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Cell Cycle Checkpoints Mitotic G1-G1/S phases Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP CDC45 LIG4 PLEKHF2 TRAPPC1 TRAPPC2 TRAPPC2L TRAPPC5 TRAPPC6A TRAPPC6B	16 interactors: CAMK1G CDK4 CDKN1A CDKN2A CEP55 MCM10 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TRAPPC3
Entrez ID		27095	8318
HPRD ID		11644	09145
Ensembl ID		ENSG00000054116	ENSG00000093009
Uniprot IDs		O43617	O75419
PDB IDs		1SZ7 2C0J 2CFH 3KXC
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport ER To Golgi Vesicle-mediated Transport DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Transport Golgi Vesicle Transport Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Neuron Death Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Ligation Involved In DNA Recombination Mitotic DNA Replication Preinitiation Complex Assembly Regulation Of Chromatin Silencing At Telomere Synaptic Growth At Neuromuscular Junction Double-strand Break Repair Via Break-induced Replication DNA-dependent DNA Replication Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Double-strand Break Repair Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Pro-B Cell Differentiation Cytoplasmic Transport Intracellular Transport Axon Choice Point Recognition Establishment Of Integrated Proviral Latency Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Neuron Remodeling Immunoglobulin V(D)J Recombination Establishment Of Viral Latency Regulation Of Cell Cycle Phase Transition DNA Recombination T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair DNA Replication Checkpoint Lymphoid Progenitor Cell Differentiation DNA Replication Positive Regulation Of Cell Cycle DNA Ligation Establishment Of Localization In Cell Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process DNA Replication Initiation DNA Replication Cell Cycle DNA-dependent DNA Replication DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Duplex Unwinding DNA Geometric Change Nucleobase-containing Compound Metabolic Process DNA Conformation Change DNA Unwinding Involved In DNA Replication Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Arrest Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Hyperoxia Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Senescence Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of B Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Organ Regeneration Cell Aging Cell Proliferation Positive Regulation Of Cell Cycle Arrest Leading Strand Elongation Regulation Of Fibroblast Proliferation Senescence-associated Heterochromatin Focus Assembly Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cell Division
Tagcloud ?		aspm bardet bbs biedl c10 c9 centrosome cilia ciliogenesis cilium hydin ift intraflagellar papd periplasmic pili rab rab11 rab8 rabin8 solenoid spd stretches tetratricopeptide tpr usher	atpgammas cmg cmgs congruencies cracked dimeric dissociating dnab duplex engages enters establishes eukaryotes explains gins handed helicase helicases helps hexamers matures mcm mcm2 separates spiral strands subcomplex subpopulation transitions
Tagcloud (Difference) ?		aspm bardet bbs biedl c10 c9 centrosome cilia ciliogenesis cilium hydin ift intraflagellar papd periplasmic pili rab rab11 rab8 rabin8 solenoid spd stretches tetratricopeptide tpr usher	atpgammas cmg cmgs congruencies cracked dimeric dissociating dnab duplex engages enters establishes eukaryotes explains gins handed helicase helicases helps hexamers matures mcm mcm2 separates spiral strands subcomplex subpopulation transitions
Tagcloud (Intersection) ?