SMC1A and ALK

		SMC1A	ALK
Description		structural maintenance of chromosomes 1A	ALK receptor tyrosine kinase
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Mitotic Spindle Pole	Plasma Membrane Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Receptor Signaling Protein Tyrosine Kinase Activator Activity Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Chromosome Organization Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Mitotic Spindle Assembly	Response To Stress Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Phosphorylation Hippocampus Development Adult Behavior Swimming Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Primary Metabolic Process Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026-resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib-resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants MDK and PTN in ALK signaling MDK and PTN in ALK signaling
Drugs			ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases		Cornelia de Lange syndrome (CdLS)	Non-small cell lung cancer
GWAS		Bipolar disorder ( 31043756) Mean corpuscular volume ( 32888494)	Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)
Interacting Genes		22 interacting genes: AMOT ATM BLM BRCA1 CEBPA ESR1 FGF14 ITSN1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2	19 interacting genes: APBB1 DUSP19 ERBB2 HES1 IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PPM1A PTN PTPN11 PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1
Entrez ID		8243	238
HPRD ID		02077	00104
Ensembl ID		ENSG00000072501	ENSG00000171094
Uniprot IDs		A0A384MR33 G8JLG1 Q14683 Q68EN4	A0A0K2YUJ3 B6D4Y2 Q9UM73
PDB IDs		6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7BTT 7JY4 7JYR 7JYS 7JYT 7LRZ 7LS0 7MZW 7MZY 7N00 7NWZ 7NX3 7NX4 7R7K 7R7R 8ARJ 9G5I 9GBE
Enriched GO Terms of Interacting Partners?		Chromosome DNA Repair DNA Metabolic Process DNA Damage Response Double-strand Break Repair DNA Recombination Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress Nuclear Matrix Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Recombinational Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Single-stranded DNA Binding Nucleoplasm Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Intracellular Signal Transduction Lateral Element Regulation Of DNA Recombination Regulation Of Cell Cycle Phase Transition DNA Replication Four-way Junction DNA Binding Signal Transduction In Response To DNA Damage Single Thymine Insertion Binding MutSalpha Complex Chromatin Binding Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chromosome, Telomeric Region Regulation Of Metabolic Process DNA Binding Nucleotide Binding Regulation Of Cell Cycle ATP Binding Single Guanine Insertion Binding Establishment Of Meiotic Sister Chromatid Cohesion	Regulation Of Apoptotic Process Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Negative Regulation Of Apoptotic Process ERBB Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Development Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cell Adhesion Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Hemopoiesis Negative Regulation Of T Cell Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation Receptor Tyrosine Kinase Binding Leukocyte Activation Positive Regulation Of Gliogenesis Intracellular Signal Transduction Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Glial Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Immune System Process Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Negative Regulation Of Lymphocyte Activation Lymphocyte Activation Cell Activation Response To Growth Factor Negative Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Leukocyte Activation Insulin-like Growth Factor Receptor Signaling Pathway
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