SMC1A and FGF14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMC1A	FGF14
Description		structural maintenance of chromosomes 1A	fibroblast growth factor 14
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Mitotic Cohesin Complex Meiotic Cohesin Complex Mitotic Spindle Pole	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Mediator Complex Binding Protein Heterodimerization Activity	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Sodium Channel Regulator Activity
	Biological Process	Mitotic Sister Chromatid Segregation DNA Repair DNA Damage Response Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Somatic Stem Cell Population Maintenance Chromosome Organization Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Mitotic Spindle Assembly	Signal Transduction JNK Cascade Cell-cell Signaling Nervous System Development Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Phase 0 - rapid depolarisation
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 31043756) Mean corpuscular volume ( 32888494)	Bone mineral density (hip) ( 30172743) Heel bone mineral density x serum urate levels interaction ( 34046847) Idiopathic downbeat nystagmus ( 32157568) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Maximum habitual alcohol consumption ( 31151762) Plasma parathyroid hormone levels ( 30134803) PR interval ( 32439900) Preeclampsia ( 23551011) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		22 interacting genes: AMOT ATM BLM BRCA1 CEBPA ESR1 FGF14 ITSN1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2	13 interacting genes: ACACA EHHADH FBXO34 FKBP8 FUNDC2 H4C7 HOXD12 MAOB RTP5 SCN8A SMC1A SYT16 TTPA
Entrez ID		8243	2259
HPRD ID		02077	03305
Ensembl ID		ENSG00000072501	ENSG00000102466
Uniprot IDs		A0A384MR33 G8JLG1 Q14683 Q68EN4	A0A7U3JVZ8 A0A9L9PX77 A0A9L9PXK7 Q92915
PDB IDs		6WG3 6WG4 6WG6 6WGE 7W1M 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG
Enriched GO Terms of Interacting Partners?		Chromosome DNA Repair DNA Metabolic Process DNA Damage Response Double-strand Break Repair DNA Recombination Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress Nuclear Matrix Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Recombinational Repair Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Checkpoint Signaling Single-stranded DNA Binding Nucleoplasm Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Intracellular Signal Transduction Lateral Element Regulation Of DNA Recombination Regulation Of Cell Cycle Phase Transition DNA Replication Four-way Junction DNA Binding Signal Transduction In Response To DNA Damage Single Thymine Insertion Binding MutSalpha Complex Chromatin Binding Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chromosome, Telomeric Region Regulation Of Metabolic Process DNA Binding Nucleotide Binding Regulation Of Cell Cycle ATP Binding Single Guanine Insertion Binding Establishment Of Meiotic Sister Chromatid Cohesion	Mitochondrial Envelope
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