MED25 and MED4

Number of citations of the paper that reports this interaction (PMID 14638676)
7

Data Source:
BioGRID (pull down)

		MED25	MED4
Gene Name		mediator complex subunit 25	mediator complex subunit 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		16 interactors: CDK8 CREBBP CTDP1 ESR1 HCFC1 MED1 MED15 MED4 MED6 MED8 MED9 NR3C1 RARA RXRA SREBF1 THRA	36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		81857	29079
HPRD ID		14380	16145
Ensembl ID		ENSG00000104973	ENSG00000136146
Uniprot IDs		Q71SY5	Q9NPJ6
PDB IDs		2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Cellular Response To Lipid Steroid Hormone Mediated Signaling Pathway Regulation Of Metabolic Process Response To Steroid Hormone Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription From RNA Polymerase II Promoter Steroid Metabolic Process Gland Development Response To Lipid Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Response To Hormone Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Negative Regulation Of Nucleic Acid-templated Transcription	Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?		allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Difference) ?		allelic appreciated approximate carrying complementing constrained constraint constructs flowering hypomorphic implies interrupted lengths minuscule occupied pft1 phenocopied photoperiod polyglutamine pursuant stark str strs thaliana traits transgene underlies undescribed varying
Tagcloud (Intersection) ?