TLR10 and CAT

Number of citations of the paper that reports this interaction (PubMedID 16482509)
45

Data Source:
HPRD (two hybrid)

		TLR10	CAT
Description		toll like receptor 10	catalase
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Catalase Complex Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding	Aminoacylase Activity Catalase Activity Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Innate Immune Response Cellular Response To Bacterial Lipopeptide	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Kidney Development Triglyceride Metabolic Process Response To Oxidative Stress Cholesterol Metabolic Process Aerobic Respiration Response To Xenobiotic Stimulus Response To UV Response To Toxic Substance Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Response To Activity Response To Inactivity Hemoglobin Metabolic Process Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Response To Ethanol Response To Cadmium Ion Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hyperoxia Cellular Detoxification Of Hydrogen Peroxide Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Amitrole Response To Phenylpropanoid
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)
Drugs			Fomepizole Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases			Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Blood protein levels ( 30072576)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	9 interacting genes: ABL1 ABL2 APP EHHADH KEAP1 OGT PTPN11 SUMO4 TLR10
Entrez ID		81793	847
HPRD ID		05884	00282
Ensembl ID		ENSG00000174123	ENSG00000121691
Uniprot IDs		Q9BXR5	A0A384P5Q0 P04040
PDB IDs		2J67	1DGB 1DGF 1DGG 1DGH 1F4J 1QQW 7P8W 7VD9 8EL9 8HID 8PVD 8SGV 8WZH 8WZJ 8WZK 8WZM
Enriched GO Terms of Interacting Partners?		Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Cellular Response To Triacyl Bacterial Lipopeptide Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Interleukin-6 Production Detection Of Bacterial Lipoprotein Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Toll-like Receptor Binding Positive Regulation Of Interleukin-8 Production Activation Of Innate Immune Response Myeloid Cell Development Inflammatory Response Cellular Response To Bacterial Lipopeptide Regulation Of Interleukin-8 Production Neutrophil Activation Involved In Immune Response Response To Bacterial Lipoprotein Detection Of Molecule Of Bacterial Origin Positive Regulation Of Interleukin-6 Production Positive Regulation Of Innate Immune Response Innate Immune Response NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Defense Response To Symbiont Defense Response To Other Organism Megakaryocyte Development Defense Response Regulation Of Inflammatory Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Neutrophil Activation Regulation Of Innate Immune Response Positive Regulation Of Defense Response Detection Of Biotic Stimulus Hemopoiesis Leukocyte Activation Involved In Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Regulation Of Neutrophil Migration	Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Response To Stress Positive Regulation Of T Cell Migration Enzyme Binding Phosphotyrosine Residue Binding Protein-containing Complex Positive Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Regulation Of Intracellular Signal Transduction Response To Oxidative Stress Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of T Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphocyte Migration ERBB Signaling Pathway Enzyme Activator Activity Bergmann Glial Cell Differentiation Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Positive Regulation Of Cell-cell Adhesion Cellular Response To Catecholamine Stimulus Positive Regulation Of Mitotic Cell Cycle Response To Catecholamine Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Mononuclear Cell Migration Regulation Of Establishment Of Cell Polarity Insulin Receptor Binding Positive Regulation Of Leukocyte Migration Actin Monomer Binding Cell Activation Involved In Immune Response Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of MAPK Cascade Ephrin Receptor Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Hemopoiesis Cellular Response To Stress Astrocyte Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway
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