TLR10 and GLDC

Number of citations of the paper that reports this interaction (PubMedID 16482509)
45

Data Source:
HPRD (two hybrid)

		TLR10	GLDC
Description		toll like receptor 10	glycine decarboxylase
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GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Glycine Cleavage Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding	Glycine Dehydrogenase (decarboxylating) Activity Electron Transfer Activity Oxidoreductase Activity Glycine Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Pyridoxal Binding
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Innate Immune Response Cellular Response To Bacterial Lipopeptide	Amino Acid Metabolic Process Glycine Metabolic Process Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Methylamine Response To Lipoic Acid Cellular Response To Leukemia Inhibitory Factor
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	Glycine degradation
Drugs			Pyridoxal phosphate
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Glycine levels ( 30837465 31070104) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Overall survival in osteosarcoma ( 29210060) Periodontal microbiota ( 22699663) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	2 interacting genes: SIRT3 TLR10
Entrez ID		81793	2731
HPRD ID		05884	01996
Ensembl ID		ENSG00000174123	ENSG00000178445
Uniprot IDs		Q9BXR5	P23378
PDB IDs		2J67	6I33 6I34 6I35
Enriched GO Terms of Interacting Partners?		Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Cellular Response To Triacyl Bacterial Lipopeptide Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Interleukin-6 Production Detection Of Bacterial Lipoprotein Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Toll-like Receptor Binding Positive Regulation Of Interleukin-8 Production Activation Of Innate Immune Response Myeloid Cell Development Inflammatory Response Cellular Response To Bacterial Lipopeptide Regulation Of Interleukin-8 Production Neutrophil Activation Involved In Immune Response Response To Bacterial Lipoprotein Detection Of Molecule Of Bacterial Origin Positive Regulation Of Interleukin-6 Production Positive Regulation Of Innate Immune Response Innate Immune Response NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Defense Response To Symbiont Defense Response To Other Organism Megakaryocyte Development Defense Response Regulation Of Inflammatory Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Defense Response Neutrophil Activation Regulation Of Innate Immune Response Positive Regulation Of Defense Response Detection Of Biotic Stimulus Hemopoiesis Leukocyte Activation Involved In Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Cytokine Production Involved In Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Regulation Of Neutrophil Migration	Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Toll-like Receptor 2 Binding Type I Interferon Receptor Binding Natural Killer Cell Activation Involved In Immune Response Histone Deacetylase Activity, NAD-dependent Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cellular Respiration Positive Regulation Of Ceramide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Regulation Of Sphingolipid Biosynthetic Process Dynein Heavy Chain Binding Dynein Light Chain Binding Outer Dynein Arm Cellular Response To Bacterial Lipopeptide NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopeptide Binding Response To Bacterial Lipoprotein NAD+ Binding Regulation Of Oxidoreductase Activity Dynein Axonemal Particle Outer Dynein Arm Assembly Regulation Of Membrane Lipid Metabolic Process NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Oxidative Phosphorylation Cytokine Receptor Binding Macromolecule Deacylation Glial Cell Projection NAD+ Poly-ADP-ribosyltransferase Activity Regulation Of Aerobic Respiration Positive Regulation Of Amide Metabolic Process 9+2 Motile Cilium Innate Immune Response Dynein Complex Axonemal Dynein Complex Assembly Response To Exogenous DsRNA Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Negative Regulation Of Reactive Oxygen Species Metabolic Process
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