VMP1 and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VMP1	CYB5R3
Description		vacuole membrane protein 1	cytochrome b5 reductase 3
Image		No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Nucleolus Vacuole Vacuolar Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endomembrane System Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Protein Binding Phospholipid Scramblase Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding
	Biological Process	Autophagosome Assembly Lipid Transport Autophagy Golgi Organization Cell Adhesion Embryo Implantation Autophagosome Membrane Docking Plasma Membrane Phospholipid Scrambling Cell Junction Assembly Lipoprotein Transport Cell-cell Adhesion Organelle Localization By Membrane Tethering Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Mitochondrion-endoplasmic Reticulum Membrane Tethering	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process
Pathways			Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases			Methemoglobinemia
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Crohn's disease ( 28067908) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494 29403010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte count ( 27863252) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549 32154731) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 27863252 32888494) White blood cell count (basophil) ( 27863252)	Initial pursuit acceleration ( 29064472)
Interacting Genes		9 interacting genes: CYB5R3 ERGIC3 FAM209A FGF13 HGS LMNA MEOX2 SLC39A9 TMEM41B	78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15
Entrez ID		81671	1727
HPRD ID		15649	08942
Ensembl ID		ENSG00000062716	ENSG00000100243
Uniprot IDs		B4DED7 B4DEJ9 B4DGZ7 K7EPE7 Q96GC9	P00387
PDB IDs			1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?			Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport
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