PRKAR2B and NBEA

Number of citations of the paper that reports this interaction (PubMedID 11102458)
56

Data Source:
HPRD (in vivo, in vitro)

		PRKAR2B	NBEA
Description		protein kinase cAMP-dependent type II regulatory subunit beta	neurobeachin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Kinase Binding
	Biological Process	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction	Intracellular Protein Localization
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Neurotransmitter receptors and postsynaptic signal transmission PKA activation NOTCH1 Intracellular Domain Regulates Transcription Assembly and cell surface presentation of NMDA receptors
Drugs		Cyclic adenosine monophosphate
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)	Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile) ( 28679651) Immunoglobulin light chain (AL) amyloidosis (serum IgG profile) ( 28679651) Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Non-muscle-invasive bladder cancer tumour size ( 31277774) Nonsyndromic cleft lip with or without cleft palate x sex interaction (2df test) ( 30277614) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Response to antipsychotic treatment in schizophrenia ( 29503163)
Interacting Genes		17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12	6 interacting genes: BMPR2 DSCR9 DTNBP1 PRKAR2A PRKAR2B STRN4
Entrez ID		5577	26960
HPRD ID		01486	05352
Ensembl ID		ENSG00000005249	ENSG00000172915
Uniprot IDs		B3KY43 P31323	B3KXQ8 Q5T321 Q8NFP9
PDB IDs			1MI1
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex	Neuronal Cell Body CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Dendritic Spine CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Protein Domain Specific Binding Ciliary Base Regulation Of CAMP/PKA Signal Transduction Retina Development In Camera-type Eye Dendrite Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Response To Antipsychotic Drug Glutamatergic Synapse Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Signal Transduction Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Cell Communication Negative Regulation Of Chondrocyte Proliferation Venous Blood Vessel Development Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Axon Extension Involved In Axon Guidance Aortic Valve Development Endochondral Bone Morphogenesis Semi-lunar Valve Development Regulation Of Intracellular Signal Transduction Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Transforming Growth Factor Beta Receptor Activity Mitral Valve Morphogenesis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Postsynapse Armadillo Repeat Domain Binding Postsynaptic Density Negative Regulation Of Dendritic Spine Development Maternal Placenta Development Lung Vasculature Development Pharyngeal Arch Artery Morphogenesis Endothelial Cell Apoptotic Process
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