PRKAR2B and AKAP11

Number of citations of the paper that reports this interaction (PMID 10864471)
23

Data Source:
HPRD (in vivo)

		PRKAR2B	AKAP11
Gene Name		protein kinase, cAMP-dependent, regulatory, type II, beta	A kinase (PRKA) anchor protein 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Ciliary Base	Peroxisome Microtubule Organizing Center
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Phosphatase 1 Binding Protein Kinase A Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Renal Water Homeostasis Energy Reserve Metabolic Process Fatty Acid Metabolic Process Water Transport Organelle Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Learning Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Movement Of Cell Or Subcellular Component Regulation Of Protein Kinase A Signaling Intracellular Signal Transduction
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition PLCG1 events in ERBB2 signaling DAP12 signaling Recruitment of mitotic centrosome proteins and complexes Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Factors involved in megakaryocyte development and platelet production Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Mitotic G2-G2/M phases Organelle biogenesis and maintenance G2/M Transition DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Loss of Nlp from mitotic centrosomes DARPP-32 events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Assembly of the primary cilium G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Signaling by FGFR Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog PLC-gamma1 signalling Centrosome maturation
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Response to antipsychotic treatment ( 20195266)	Bone mineral density ( 22504420) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		14 interactors: AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 GNAI3 KIF5B LASP1 MAATS1 NBEA TAF12	6 interactors: GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B
Entrez ID		5577	11215
HPRD ID		01486	05261
Ensembl ID		ENSG00000005249	ENSG00000023516
Uniprot IDs		B3KY43 P31323	Q9UKA4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase A Signaling Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transport Cellular Response To CAMP Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Membrane Potential Positive Regulation Of Transporter Activity Positive Regulation Of Ion Transmembrane Transport Regulation Of CAMP Biosynthetic Process Stress Granule Disassembly Regulation Of CAMP Metabolic Process Blood Coagulation Hemostasis Response To CAMP Positive Regulation Of Delayed Rectifier Potassium Channel Activity Protein Localization Positive Regulation Of Protein Kinase A Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Organophosphorus Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Body Fluid Levels Regulation Of Signaling Synaptic Transmission Wound Healing Response To Purine-containing Compound Cytoplasm Organization Regulation Of Ion Transport Regulation Of Delayed Rectifier Potassium Channel Activity Response To Wounding Positive Regulation Of Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sexual Reproduction Positive Regulation Of Synaptic Transmission, GABAergic Transport	Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Generation Of Precursor Metabolites And Energy Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase A Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Renal Water Homeostasis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Oxidation-reduction Process Cellular Response To Glucagon Stimulus Negative Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Water Transport Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Fluid Transport Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance Glycogen Metabolic Process Water Homeostasis Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Phospholipase Activity Polysaccharide Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Phosphorylation Renal System Process Response To Organic Substance Cell Cycle Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Circadian Rhythm Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Triglyceride Catabolic Process Regulation Of Insulin Secretion Positive Regulation Of Protein Phosphorylation
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?