PRKAR2B and AKAP11

Number of citations of the paper that reports this interaction (PubMedID 10864471)
0

Data Source:
HPRD (in vivo)

		PRKAR2B	AKAP11
Description		protein kinase cAMP-dependent type II regulatory subunit beta	A-kinase anchoring protein 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse	Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Binding Protein Phosphatase 1 Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction	Renal Water Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Protein Localization Cortical Actin Cytoskeleton Organization Intracellular Signal Transduction Protein Localization To Endosome
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Cyclic adenosine monophosphate
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740) Bone mineral density (spine) ( 19801982) Crohn's disease ( 28067908) Hepcidin levels ( 27846281) Inflammatory bowel disease ( 28067908) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Serum alkaline phosphatase levels ( 33339817 33547301) Type 1 diabetes ( 34012112 34127860)
Interacting Genes		17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12	8 interacting genes: GSK3A GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B WEE2-AS1
Entrez ID		5577	11215
HPRD ID		01486	05261
Ensembl ID		ENSG00000005249	ENSG00000023516
Uniprot IDs		B3KY43 P31323	Q9UKA4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex	Protein Kinase A Catalytic Subunit Binding CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Postsynapse CAMP Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Metabolic Process Ciliary Base Regulation Of Glycogen (starch) Synthase Activity Regulation Of CAMP/PKA Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Protein Domain Specific Binding Glutamatergic Synapse Cellular Response To Interleukin-3 PTW/PP1 Phosphatase Complex Rhythmic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Beta-catenin Destruction Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Carbohydrate Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Tau-protein Kinase Activity Dendritic Spine Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Phosphatase 1 Binding Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Membrane Permeability Plasma Membrane Raft Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Presynapse
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