IFT88 and PDX1

		IFT88	PDX1
Description		intraflagellar transport 88	pancreatic and duodenal homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Manchette Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Intraciliary Transport Particle B Motile Cilium Centriolar Satellite Ciliary Basal Body Sperm Flagellum Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Tip Ciliary Base Non-motile Cilium Sperm Head-tail Coupling Apparatus	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding Kinesin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Kidney Development Cell Projection Organization Response To Silicon Dioxide Intraciliary Anterograde Transport Intraciliary Transport Positive Regulation Of Cilium Assembly Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Glucose Animal Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Glucose Mediated Signaling Pathway Regulation Of Gene Expression Morphogenesis Of Embryonic Epithelium Insulin Secretion Cell Differentiation Pancreas Development Exocrine Pancreas Development Endocrine Pancreas Development Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Vitamin Response To Lipid Response To Cytokine Response To Nicotine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Enteroendocrine Cell Differentiation Regulation Of Cell Population Proliferation Glucose Homeostasis Response To L-leucine Response To Alkaloid Type B Pancreatic Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Transdifferentiation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Response To Fatty Acid Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Acadesine Positive Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells Developmental Lineage of Pancreatic Ductal Cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases			Permanent neonatal diabetes mellitus (PNDM) Pancreatic agenesis Maturity onset diabetes of the young (MODY)
GWAS		Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)	Acute insulin response ( 28490609) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Birth weight ( 31043758) Blood sugar levels ( 29403010) Body mass index ( 26426971) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 28270201) Glycated hemoglobin levels ( 28898252) Pancreatic cancer ( 25086665 26098869 29422604) Peak insulin response ( 28490609)
Interacting Genes		14 interacting genes: CACNA1C CAPN7 CCDC120 DSCAM EEF2KMT EML2 FBXO7 HUNK ITPKB MSRB1 PRRC2A RPGR SMARCE1 VHL	13 interacting genes: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6
Entrez ID		8100	3651
HPRD ID		09000	02843
Ensembl ID		ENSG00000032742	ENSG00000139515
Uniprot IDs		A0A140VJL7 B3KX42 Q13099	P52945
PDB IDs			6F8F 7KPK
Enriched GO Terms of Interacting Partners?			DNA-dependent Protein Kinase Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA End Binding Ku70:Ku80 Complex Small-subunit Processome Assembly Positive Regulation Of Macromolecule Biosynthetic Process Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein-DNA Complex DNA Binding Chromatin DNA-binding Transcription Factor Activity Regulation Of Cell Differentiation Leukocyte Differentiation B Cell Lineage Commitment Response To Gamma Radiation Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding 5'-deoxyribose-5-phosphate Lyase Activity Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Positive Regulation Of RNA Metabolic Process DNA Recombination U3 SnoRNA Binding Positive Regulation Of Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hormone Secretion Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Telomere Maintenance Hormone Transport Regulation Of Gene Expression V(D)J Recombination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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