IFT88 and CAPN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IFT88	CAPN7
Description		intraflagellar transport 88	calpain 7
Image		No pdb structure
GO Annotations	Cellular Component	Manchette Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Intraciliary Transport Particle B Motile Cilium Centriolar Satellite Ciliary Basal Body Sperm Flagellum Cell Projection Intercellular Bridge Mitotic Spindle Ciliary Tip Ciliary Base Non-motile Cilium Sperm Head-tail Coupling Apparatus	Nucleus Centrosome Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Kinesin Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity MIT Domain Binding
	Biological Process	Kidney Development Cell Projection Organization Response To Silicon Dioxide Intraciliary Anterograde Transport Intraciliary Transport Positive Regulation Of Cilium Assembly Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly	Proteolysis Positive Regulation Of Epithelial Cell Migration Self Proteolysis
Pathways		Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)	Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: CACNA1C CAPN7 CCDC120 DSCAM EEF2KMT EML2 FBXO7 HUNK ITPKB MSRB1 PRRC2A RPGR SMARCE1 VHL	19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655
Entrez ID		8100	23473
HPRD ID		09000	05908
Ensembl ID		ENSG00000032742	ENSG00000131375
Uniprot IDs		A0A140VJL7 B3KX42 Q13099	Q7Z479 Q9Y6W3
PDB IDs			2QFE 8UC6
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Cell Population Proliferation Identical Protein Binding Cell Division Negative Regulation Of Catabolic Process Regulation Of Cell Cycle Centrosome Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cytoplasm Ubiquitin-protein Transferase Activity Negative Regulation Of Autophagy Atrioventricular Valve Morphogenesis Negative Regulation Of Cell Cycle Process Midbody Abscission Regulation Of Primary Metabolic Process Mitotic Cytokinetic Process Mitotic Spindle Protein Ubiquitination Flemming Body Spindle Pole Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytokinetic Process Regulation Of Cell Cycle Process Molecular Adaptor Activity MAD1 Complex Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Heart Valve Morphogenesis Proteasomal Protein Catabolic Process Post-translational Protein Modification Transcription Repressor Complex Protein Stabilization Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
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