ALX1 and GRP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALX1	GRP
Description		ALX homeobox 1	gastrin releasing peptide
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus Nuclear Body	Extracellular Region Extracellular Space Cytoplasmic Vesicle Secretory Granule Lumen Cell Projection Neuron Projection
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Embryonic Limb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Embryonic Skeletal System Morphogenesis Stem Cell Development Roof Of Mouth Development	Signal Transduction Neuropeptide Signaling Pathway Social Behavior Psychomotor Behavior Response To External Biotic Stimulus Mast Cell Degranulation Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Behavioral Fear Response
Pathways			Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events
Drugs
Diseases		Frontonasal dysplasia
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Medication use (drugs used in diabetes) ( 31015401) Pancreas volume ( 34128465) Pancreatic cancer ( 26098869 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Venous thromboembolism ( 32232851)
Interacting Genes		17 interacting genes: ALX4 APCS CLIC3 CREBBP EEF1D EP300 GRP IPO13 KAT5 KRTAP4-4 OR52L1 PACRGL RARA RBM45 SRA1 UROC1 ZNF300	5 interacting genes: ALX1 DPP4 GRPR MEP1A MEP1B
Entrez ID		8092	2922
HPRD ID		03316	08845
Ensembl ID		ENSG00000180318	ENSG00000134443
Uniprot IDs		Q15699 V9HWA7	A0A140VJM7 P07492
PDB IDs			2N0B 2N0C 2N0D 2N0E 2N0F 2N0G 2N0H 7W3Z 8H0Q
Enriched GO Terms of Interacting Partners?		Peptide Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Acetylation Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Transcription Regulator Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone Acetyltransferase Activity Protein Acetylation Transcription Coactivator Binding DNA-binding Transcription Factor Binding N-terminal Protein Amino Acid Acetylation Histone H4 Acetyltransferase Activity Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Myoblast Differentiation Acyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Radiation Regulation Of Defense Response Regulation Of Hemopoiesis Innate Immune Response-activating Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Radiation Tau Protein Binding Positive Regulation Of Defense Response Positive Regulation Of Leukocyte Differentiation Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity	Meprin A Complex Psychomotor Behavior Motor Behavior Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Glucagon Processing Metalloendopeptidase Activity Epidermal Growth Factor Receptor Ligand Maturation Metallopeptidase Activity Hormone Metabolic Process Protein Processing Positive Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Neutrophil Chemotaxis Intercellular Canaliculus Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Neutrophil Migration Positive Regulation Of Behavioral Fear Response Mesenchymal Cell Development Positive Regulation Of Fear Response Metallodipeptidase Activity Protein Maturation Negative Regulation Of Extracellular Matrix Disassembly Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Cell-cell Adhesion Mediated By Integrin Dipeptidyl-peptidase Activity Virion Attachment To Host Cell Proteolysis Regulation Of Behavioral Fear Response Adhesion Of Symbiont To Host Endocytosis Involved In Viral Entry Into Host Cell Locomotory Exploration Behavior Neuropeptide Receptor Activity Negative Regulation Of Extracellular Matrix Organization Lamellipodium Membrane Negative Regulation Of Leukocyte Chemotaxis Regulation Of Extracellular Matrix Disassembly Hydrolase Activity Chemorepellent Activity Regulation Of Respiratory Gaseous Exchange Neuropeptide Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Behavior
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