ALX1 and UROC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALX1	UROC1
Description		ALX homeobox 1	urocanate hydratase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus Nuclear Body	Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Urocanate Hydratase Activity Lyase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Mesenchymal Cell Development Embryonic Limb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Embryonic Skeletal System Morphogenesis Stem Cell Development Roof Of Mouth Development	L-histidine Metabolic Process L-histidine Catabolic Process L-histidine Catabolic Process To Glutamate And Formamide L-histidine Catabolic Process To Glutamate And Formate
Pathways			Histidine catabolism
Drugs
Diseases		Frontonasal dysplasia
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)	Anorectal malformation ( 31136621) Cerebellum cortex volume ( 31530798) Fast beta electroencephalogram ( 28040410) Heel bone mineral density ( 30598549) Periventricular white matter hyperintensities ( 32517579) Post bronchodilator FEV1 ( 26634245) Rapid automised naming of letters ( 30741946) Recurrence of malaria infection (mild or asymptomatic) ( 31667592) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		17 interacting genes: ALX4 APCS CLIC3 CREBBP EEF1D EP300 GRP IPO13 KAT5 KRTAP4-4 OR52L1 PACRGL RARA RBM45 SRA1 UROC1 ZNF300	1 interacting genes: ALX1
Entrez ID		8092	131669
HPRD ID		03316	08712
Ensembl ID		ENSG00000180318	ENSG00000159650
Uniprot IDs		Q15699 V9HWA7	Q96N76
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptide Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Acetylation Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Peptide Crotonyltransferase Activity Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Transcription Regulator Complex Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone Acetyltransferase Activity Protein Acetylation Transcription Coactivator Binding DNA-binding Transcription Factor Binding N-terminal Protein Amino Acid Acetylation Histone H4 Acetyltransferase Activity Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Myoblast Differentiation Acyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Radiation Regulation Of Defense Response Regulation Of Hemopoiesis Innate Immune Response-activating Signaling Pathway Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Radiation Tau Protein Binding Positive Regulation Of Defense Response Positive Regulation Of Leukocyte Differentiation Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity	Mesenchymal Cell Development Limb Morphogenesis Embryonic Organ Morphogenesis Stem Cell Development Tube Closure Skeletal System Morphogenesis Roof Of Mouth Development Embryonic Limb Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Tube Formation Neural Tube Closure
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