SLC48A1 and LAMP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC48A1	LAMP1
Description		solute carrier family 48 member 1	lysosomal associated membrane protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Phagolysosome Membrane	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Sarcolemma Melanosome Cytolytic Granule Autolysosome Phagocytic Vesicle Perinuclear Region Of Cytoplasm Phagolysosome Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane Cytolytic Granule Membrane
	Molecular Function	Protein Binding Heme Transmembrane Transporter Activity Heme Binding	Virus Receptor Activity Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding
	Biological Process	Phagocytosis Lysosomal Transport Heme Transport Erythrocyte Differentiation Heme Metabolic Process Localization Of Cell Heme Export Heme Export From Vacuole To Cytoplasm	Lysosomal Lumen Acidification Lysosomal Lumen PH Elevation Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Protein Stabilization Establishment Of Protein Localization To Organelle Golgi To Lysosome Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Regulation Of Organelle Transport Along Microtubule Proton Transmembrane Transport
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Asthma (adult onset) ( 31036433) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494)	Bipolar disorder ( 31043756)
Interacting Genes		9 interacting genes: APP COMT FXR1 LAMP1 LDAF1 MEOX2 SHANK3 TMEM14B UNC93A	4 interacting genes: AP1M1 AP2M1 SLC48A1 VSTM1
Entrez ID		55652	3916
HPRD ID		07916	01076
Ensembl ID		ENSG00000211584	ENSG00000185896
Uniprot IDs		Q6P1K1	B3KRY3 P11279
PDB IDs			8ATH 8FY5 8FYF 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Associative Learning Negative Regulation Of Long-term Synaptic Potentiation Memory Positive Regulation Of Long-term Synaptic Potentiation Learning Response To Catecholamine Dendritic Spine Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Learning Or Memory Amyloid-beta Complex Growth Cone Lamellipodium Cognition Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Norepinephrine Secretion Catechol O-methyltransferase Activity Neuron Projection Regulation Of Synaptic Transmission, Glutamatergic Synapse Acetylcholine Receptor Activator Activity Axon Lipoprotein Particle Positive Regulation Of Protein Import Cellular Response To Phosphate Starvation Guanylate Kinase-associated Protein Clustering PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Dendrite Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Neuromuscular Process Phagolysosome Membrane Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation	Clathrin Adaptor Complex Clathrin Adaptor Activity Lysosomal Membrane Heme Export From Vacuole To Cytoplasm Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Cytoplasmic Vesicle Plasma Membrane Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Endolysosome Heme Transmembrane Transport Heme Transmembrane Transporter Activity Localization Of Cell Heme Export Heme Transport Phagolysosome Membrane Vacuolar Transmembrane Transport Vesicle-mediated Transport Intracellular Transport Positive Regulation Of Fatty Acid Beta-oxidation Cellular Response To Endothelin Endosome To Melanosome Transport Vesicle Organization AP-2 Adaptor Complex Response To Endothelin Regulation Of Type B Pancreatic Cell Proliferation AP-1 Adaptor Complex Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Fatty Acid Oxidation Regulation Of Vesicle Size Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Melanosome Assembly Iron Ion Transmembrane Transport Endolysosome Membrane Regulation Of B Cell Apoptotic Process Cellular Localization Endocytosis Establishment Of Localization In Cell Clathrin-coated Endocytic Vesicle
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