ZNF423

Description		zinc finger protein 423
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GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Nervous System Development Cell Differentiation Positive Regulation Of BMP Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Protein Localization To Cilium Negative Regulation Of Cold-induced Thermogenesis
Pathways		Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases		Systemic lupus erythematosus
GWAS		A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Inattentive symptoms ( 18821565) Mean spheric corpuscular volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Neutrophil count ( 32888494) Number of sexual partners ( 30643258) Red blood cell count ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494) Word spelling ( 30741946)
Novel Interacting Genes		1 novel interacting genes: CSNK2A2
Interacting Genes		9 interacting genes: APP BRCA1 EBF1 FXR1 PARP1 SMAD1 SMAD4 TSC1 USP7
Entrez ID		23090
HPRD ID		05189
Ensembl ID		ENSG00000102935
Uniprot IDs		A0A7P0Q1F0 B3KNG7 B7Z9C7 F5H7S1 Q2M1K9
PDB IDs		2MDG
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication SMAD Protein Complex Heteromeric SMAD Protein Complex Regulation Of MiRNA Transcription Cellular Response To Growth Factor Stimulus Negative Regulation Of Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of Circadian Rhythm Reproductive Process Regulation Of Signal Transduction Response To Growth Factor Negative Regulation Of Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Small Molecule Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation I-SMAD Binding Cardiac Conduction System Development Response To Stress Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Nucleus Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of Circadian Sleep/wake Cycle Regulation Of Cell Communication Regulation Of Signaling Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Organization R-SMAD Binding Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Gamete Generation Chromatin
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