ZNF423 and EBF1

Number of citations of the paper that reports this interaction (PMID 9151733)
29

Data Source:
HPRD (in vivo, in vitro)

		ZNF423	EBF1
Gene Name		zinc finger protein 423	early B-cell factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding Protein Dimerization Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Transcription, DNA-templated Notch Signaling Pathway Nervous System Development Cell Differentiation Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated
Pathways			Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Inattentive symptoms ( 18821565)	Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Blood pressure ( 21909110) Breast cancer ( 23535729 23535733) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Obesity-related traits ( 23251661) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		6 interactors: BRCA1 EBF1 PARP1 SMAD1 SMAD4 USP7	6 interactors: ATPAF2 CREBBP HOMEZ PAX5 ZNF423 ZNF521
Entrez ID		23090	1879
HPRD ID		05189	01256
Ensembl ID		ENSG00000102935	ENSG00000164330
Uniprot IDs		B3KNG7 F5H7S1 Q2M1K9	Q9UH73
PDB IDs		2MDG	3LYR 3MQI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Biosynthetic Process Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression BMP Signaling Pathway Developmental Process Nitrogen Compound Metabolic Process Embryonic Pattern Specification Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Cellular Response To Growth Factor Stimulus DNA Repair Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Response To Growth Factor Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Response To Stress Mesonephros Development Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Nephrogenic Mesenchyme Morphogenesis Positive Regulation Of Histone H3-K9 Acetylation Mesoderm Development	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Notch Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Proton-transporting ATP Synthase Complex Assembly N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Germ-line Stem Cell Maintenance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Histone Methylation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of BMP Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Histone Methylation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Skeletal Muscle Cell Differentiation Cellular Response To Heat Multicellular Organismal Development Transcription From RNA Polymerase II Promoter
Tagcloud ?		1a1 aldehyde aldh1a1 cd19 dehydrogenase deregulation ectopic finger fos hematological highlight hoxa10 igg1 jun myeloma oncogene oncogenesis peroxisome pparg producing proliferator proto rara rescued sequential splenic splenocytes splenomegaly	collaborate concert coordinate cues decades e2a epigenetic establish establishing extrinsic fate fates foxo1 guide ikaros landscape lineage lineages lock loops lymphopoiesis modifiers modify pax permissive prime pu repress runx1
Tagcloud (Difference) ?		1a1 aldehyde aldh1a1 cd19 dehydrogenase deregulation ectopic finger fos hematological highlight hoxa10 igg1 jun myeloma oncogene oncogenesis peroxisome pparg producing proliferator proto rara rescued sequential splenic splenocytes splenomegaly	collaborate concert coordinate cues decades e2a epigenetic establish establishing extrinsic fate fates foxo1 guide ikaros landscape lineage lineages lock loops lymphopoiesis modifiers modify pax permissive prime pu repress runx1
Tagcloud (Intersection) ?