APOL3 and SGCB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOL3	SGCB
Description		apolipoprotein L3	sarcoglycan beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma
	Molecular Function	Lipid Transporter Activity Protein Binding Lipid Binding	Protein Binding
	Biological Process	Lipid Transport Inflammatory Response Lipoprotein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction	Muscle Organ Development Response To Glucose Gene Expression Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Muscle Cell Development Cardiac Muscle Cell Development Vascular Associated Smooth Muscle Cell Development
Pathways			Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Total intracranial volume ( 31530798)
Interacting Genes		33 interacting genes: AQP6 CYB5R3 ELOVL4 FAM209A FATE1 FXYD6-FXYD2 GJA8 GJB1 GJB5 GJC1 GPR152 GPRC5D HAS3 IL7R LHFPL5 LINC00839 LRRC25 MFSD6 NCALD PMP22 RNF19B SGCB SLC10A1 SLC16A2 SLC1A5 SLC35H1 SLC7A14 STX1A TIMMDC1 TMEM167B TMEM237 TMEM52B TNFRSF10D	22 interacting genes: ADAM33 ADRA1A APOL3 ATP1B4 CLEC7A CMTM5 EHHADH HTR2C LTB4R2 MAL MGST2 NINJ1 PTTG1IP SGCA SGCD SGCG SGCZ SLC52A1 SMIM3 TMEM11 TNF TRIM63
Entrez ID		80833	6443
HPRD ID		06264	02942
Ensembl ID		ENSG00000128284	ENSG00000163069
Uniprot IDs		O95236	Q16585 Q5U0N0
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Transmembrane Transport Amino Acid Transmembrane Transporter Activity Gap Junction Assembly Plasma Membrane Organic Anion Transport Amino Acid Transmembrane Transport	Sarcoglycan Complex Dystroglycan Complex Membrane Heart Contraction Muscle Contraction Heart Process Sarcolemma Muscle System Process Circulatory System Process Plasma Membrane Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Action Potential Cardiac Muscle Tissue Development Negative Regulation Of Heart Rate Dystrophin-associated Glycoprotein Complex Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Heart Contraction Negative Regulation Of Blood Circulation Muscle Organ Development Negative Regulation Of Myoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Ferroptosis Muscle Structure Development Muscle Tissue Development Negative Regulation Of Bile Acid Secretion Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Metabolic Process Detection Of Yeast Detection Of Molecule Of Fungal Origin Positive Regulation Of Inflammatory Response Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure System Process Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity
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